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Induced pluripotent stem cells in psychiatry: a critical review
(2021-01)
A key challenge in psychiatry research is the development of high-fidelity model systems that can be experimentally manipulated to explore and test pathophysiological mechanisms of illness. In this respect, the emerging ...
Functional Connectivity between Task-Positive Networks and the Left Precuneus as a Biomarker of Response to Lamotrigine in Bipolar Depression: A Pilot Study
(2021-06)
Treatment of bipolar depression poses a significant clinical challenge. Lamotrigine is one of a few efficacious drugs, however, it needs to be titrated very slowly and response can only be assessed after 10–12 weeks. With ...
Effect of lithium on circadian rhythm in bipolar disorder: A systematic review and meta-analysis
(2021-03)
Circadian rhythm disruption is commonly reported in patients with bipolar disorder. Lithium has been suggested to have effects on the circadian clock, the biological basis of the circadian rhythm. The objective of the ...
The costs of bipolar disorder in the United Kingdom
(2021-09)
Objectives: To estimate the individual cost and population-level economic burden of Bipolar Disorder (BD), and explore the impact of clinical and sociodemographic factors on costs in the United Kingdom.
Methods: Annual ...
Characterising the severity of treatment resistance in unipolar and bipolar depression
(2021-10)
Treatment-resistant depression (TRD) is classically defined according to the number of suboptimal antidepressant responses experienced, but multidimensional assessments of TRD are emerging and may confer some advantages. ...
Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)
(2021-07)
Treatment Resistant Bipolar Depression (TRBD) is a major contributor to the burden of disease associated with Bipolar Disorder (BD). Treatment options for people experiencing bipolar depression are limited to three ...
Behavioural sleep and circadian rhythm interventions in bipolar disorder: a systematic review of randomised controlled trials
(2021-07)
Sleep and circadian rhythm disruptions are prominent symptoms of bipolar
disorder (BD) and potential targets for adjunctive behavioural intervention. The aim of this
systematic review was to appraise evidence from ...
Onset and recurrence of psychiatric disorders associated with anti-hypertensive drug classes
(2021-05)
The major anti-hypertensive (AHT) drug classes have been associated with differential risks of psychiatric disorders. However, existing data are limited largely to depression, and confounding variables have not always been ...
Appraisal of patient-level health economic models of severe mental illness: systematic review
(2021-08)
Healthcare decision makers require accurate long-term economic models to evaluate the cost-effectiveness of new mental health interventions.
Aims
To assess the suitability of current patient-level economic models to ...