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Changes in daily mental health service use and mortality at the commencement and lifting of COVID-19 'lockdown' policy in 10 UK sites: a regression discontinuity in time design
(2021-05)
Objectives: To investigate changes in daily mental health (MH) service use and mortality in response to the introduction and the lifting of the COVID-19 'lockdown' policy in Spring 2020.
Design: A regression discontinuity ...
Magnitude and variability of structural brain abnormalities in neuropsychiatric disease: protocol for a network meta-analysis of MRI studies
(2021-04)
Introduction Structural MRI is the most frequently used method to investigate brain volume alterations in neuropsychiatric disease. Previous meta-analyses have typically focused on a single diagnosis, thereby precluding ...
A dose-effect network meta-analysis model: an application in antidepressants
(2021-04)
Network meta-analysis (NMA) has been used to answer a range of clinical questions about the preferable intervention for a given condition. Although the effectiveness and safety of pharmacological agents depend on the dose ...
Systematic Review and Meta-analysis: Depressive Symptoms and Risky Behaviors Among Adolescents in Low- and Middle-Income Countries
(2021-05)
Several studies conducted in high-income countries have found an association between depressive symptoms and risky behaviors among adolescents. Evidence from low- and middle-income countries (LMICs), where 90% of the world’s ...
Psychologic Treatment of Depression Compared With Pharmacotherapy and Combined Treatment in Primary Care: A Network Meta-Analysis
(2021-05)
PURPOSE Most patients with depression are treated by general practitioners, and most of those patients prefer psychotherapy over pharmacotherapy. No network meta-analyses have examined the effects of psychotherapy compared ...
How Efficacious Are Antipsychotic Drugs for Schizophrenia? An Interpretation Based on 13 Effect Size Indices
(2021-08)
Background
The magnitude of the superiority of antipsychotics over placebo is debated. One reason is that the effect-size index which is usually used in meta-analyses is in standard deviation units. Many other indices, ...
Effect of lithium on circadian rhythm in bipolar disorder: A systematic review and meta-analysis
(2021-03)
Circadian rhythm disruption is commonly reported in patients with bipolar disorder. Lithium has been suggested to have effects on the circadian clock, the biological basis of the circadian rhythm. The objective of the ...
Quantifying the heterogeneity of cognitive functioning in Alzheimer’s disease to extend the placebo-treatment dichotomy: Latent class analysis of individual-participant data from five pivotal randomized clinical trials of donepezil
(2021-02)
Background. The extent and profiles of heterogeneity in cognitive functioning among participants in clinical trials of antidementia medication are unknown. We aimed to quantify and
identify profiles of heterogeneity of ...
COVID-19 vaccines, hesitancy and mental health
(2021-04)
‘None of us will be safe until everyone is
safe. Global access to coronavirus vaccines,
tests and treatments for everyone who
needs them, anywhere, is the only way
out’. This statement by Dr Tedros
Adhanom Ghebreyesus, ...
Initial treatment choices to achieve sustained response in major depression: a systematic review and network meta-analysis
(2021-10)
Major depression is often a relapsing disorder. It is therefore important to start its treatment with therapies that maximize the chance of not
only getting the patients well but also keeping them well. We examined the ...