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Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity.
(2018-12-17)
Psychosocial stressors including childhood adversity, migration, and living in an urban environment, have been
associated with several psychiatric disorders, including psychotic disorders. The neural and psychological ...
Is there a choice to make? A pilot study investigating attitudes towards treatment in an Early Intervention for Psychosis service
(2018-03)
Purpose
The purpose of this paper is to investigate health care professionals’ (HCPs) and service-users’ (SUs) attitudes towards different treatment options in an Early Intervention for Psychosis (EIP) service as well as ...
Study of immunotherapy in antibody positive psychosis: feasibility and acceptability (SINAPPS1)
(2018-06-11)
The main finding of the SINAPPS1 study is that immunotherapy can be delivered rapidly and safely to people with acute psychosis within an acute hospital setting. The treatments were tolerated and there were no cases of ...
Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis
(2018-01-30)
Preclinical models propose that the onset of psychosis is associated with hippocampal hyperactivity, thought to be driven by
cortical GABAergic interneuron dysfunction and disinhibition of pyramidal neurons. Recent ...
Efficacy and Acceptability of Interventions for Attenuated Positive Psychotic Symptoms in Individuals at Clinical High Risk of Psychosis: A Network Meta-Analysis
(2018-06-12)
Background: Attenuated positive psychotic symptoms represent the defining features of the clinical high-risk for psychosis (CHR-P) criteria. The effectiveness of each available treatment for reducing attenuated positive ...
Sleep Disorders in Early Psychosis: Incidence, Severity, and Association With Clinical Symptoms
(2018-09-08)
Sleep disturbance is known to be associated with psychosis, but sleep disorders (eg. insomnia, nightmare disorder, sleep apnea) have rarely been investigated. We aimed to provide the first detailed assessment of sleep ...
Adapted CBT to Stabilize Sleep on Psychiatric Wards: a Transdiagnostic Treatment Approach
(2018-04-04)
Background: Almost all patients admitted at acute crisis to a psychiatric ward experience clinically significant symptoms of insomnia. Ward environments pose challenges to both sleep and the delivery of therapy. Despite ...
The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study
(2018-06)
Whilst the role of the Disrupted-in-Schizophrenia 1 (DISC1) gene in the aetiology of major mental illnesses is debated, the characterisation of its function lends it credibility as a candidate. A key aspect of this functional ...
The Experience of Sleep Problems and Their Treatment in Young People at Ultra-High Risk of Psychosis: A Thematic Analysis
(2018-08)
We view sleep disruption as a contributory causal factor in the development of psychotic experiences. Clinical trials indicate that psychological interventions targeting insomnia result in improvements in both sleep and ...