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The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function
(2019)
Genome-wide association studies (GWAS) of psychiatric phenotypes have tended to focus on categorical diagnoses, but to understand the biology of mental illness it may be more useful to study traits which cut across traditional ...
Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal
(2019-06)
We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and ...
Which Dopamine Polymorphisms are Functional? Systematic Review and Meta-Analysis of COMT, DAT, DBH, DDC, DRD1-5, MAOA, MAOB, TH, VMAT1 and VMAT2
(2019-05)
BACKGROUND: Many polymorphisms in dopamine genes are reported to affect cognitive, imaging or
clinical phenotypes. It is often inferred or assumed that such associations are causal, mediated by a direct
effect of the ...