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Multifactorial interventions for preventing falls in older people living in the community: a systematic review and meta-analysis of 41 trials and almost 20 000 participants
(2019-08)
Objective To assess the longer term effects of multifactorial interventions for preventing falls in older people living in the community, and to explore whether prespecific trial-level characteristics are associated with ...
Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study
(2020-03)
Cardiovascular health in midlife is an established risk factor for cognitive function later in life. Knowing mechanisms of this associationmay allow preventative steps to be taken to preserve brain health and cognitive ...
Prediction of brain age and cognitive age: quantifying brain and cognitive maintenance in aging
(2020-06)
The concept of brain maintenance refers to the preservation of brain integrity in older age, whilecognitive reserverefers to the capacity to maintain cognition in the presence of neurodegeneration or aging-related brain ...
Associations Between Longitudinal Trajectories of Cognitive and Social Activities and Brain Health in Old Age
(2020-08)
Importance Prior neuroimaging studies have found that late-life participation in cognitive (eg, reading) and social (eg, visiting friends and family) leisure activities are associated with magnetic resonance imaging (MRI) ...
Right Lateralized Brain Reserve Offsets Age-Related Deficits in Ignoring Distraction
(2020-09)
Age-related deterioration of attention decreases the ability to stay focused on the task at hand due to less efficient selection
of relevant information and increased distractibility in the face of irrelevant, but salient ...
Deprescribing antihypertensives in patients with multimorbidity
(2020-10)
Deprescribing preventative medications
such as antihypertensives may reduce
adverse events in some older adults,
leading to improved quality of life. The
Optimising Treatment for Mild Systolic
Hypertension in the ...
Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol
(2018-11)
Introduction: Neurogenic claudication due to spinal stenosis is common in older adults. The effectiveness of conservative interventions is not known. The aim of the study is to estimate the clinical and cost-effectiveness ...
Connections Between Insomnia and Cognitive Aging.
(2019-06)
Insomnia is a common sleep disorder among older adults, and a risk factor for poor physical and mental health. However, the relationship between insomnia and cognitive health is not well understood. Here, we review ...
Blood pressure changes following antihypertensive medication reduction, by drug class and dose chosen for withdrawal: Exploratory analysis of data from the OPTiMISE trial
(2021-02)
Aims: Deprescribing of antihypertensive drugs is recommended for some older patients with
polypharmacy, but there is little evidence to inform which drug (or dose) should be
withdrawn. This study used data from the ...
Risk Factors for Mobility Decline in Community-Dwelling Older Adults: A Systematic Literature Review
(2021-08)
Mobility is essential to maintaining independence for older adults. This systematic review aimed to summarize evidence about
self-reported risk factors for self-reported mobility decline; and to provide an overview of ...