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Stress, inflammation and hippocampal subfields in depression: A 7 Tesla MRI Study
(2020-02)
Experiencing stressful events throughout one’s life, particularly childhood trauma, increases the likelihood of being diagnosed with Major Depressive Disorder (MDD). Raised levels of cortisol, and markers of inflammation ...
Changes in brain Glx in depressed bipolar patients treated with lamotrigine: A proton MRS study
(2019-03)
Background
Lamotrigine is a useful treatment in bipolar depression but requires several weeks of dose titration before its clinical effects can be assessed. Animal experimental studies suggest that lamotrigine lowers ...
Brain glutamate concentration in men with early psychosis: a magnetic resonance spectroscopy case–control study at 7 T
(2021-06)
Abnormalities in glutamate neurotransmission are linked to psychotic symptoms and cognitive dysfunction in schizophrenia. magnetic resonance spectroscopy (MRS) provides an acceptable means of measuring glutamate in the ...
Predicting treatment response in depression: the role of anterior cingulate cortex
(2018)
Background:
Identification of biomarkers predicting therapeutic outcome to antidepressant treatment is one of the most important tasks in current research because it may transform the lengthy process of finding the right ...
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
(2020-09)
Rationale
Lithium is an effective prophylactic and anti-manic treatment in bipolar disorder; however, its use is declining through perceived poor tolerance and toxicity. Lithium inhibits inositol monophosphatase (IMPase), ...
Translating the promise of 5HT4 receptor agonists for the treatment of depression
(2020-02)
Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel
target for the treatment of depression and cognitive impairment. 5-HT4 receptors are postsynaptic
receptors that are located in ...