Browsing Conditions, Lifestyle Factors & Interventions by Title
Now showing items 118-137 of 910
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Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder
(2023-07)JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral interleukin (IL)-1β release, and attenuated ... -
Characterizing Affective Variability in Bipolar Disorder and Borderline Personality Disorder, and the Effects of Lithium, Using a Generative Model of Affect
(2022-02)The affective variability of Bipolar Disorder (BD) is thought to qualitatively differ from that of Borderline Personality Disorder (BPD), with changes in affect persisting for longer in BD. However, quantitative studies ... -
Characterizing the Digital Health Citizen: Mixed-Methods Study Deriving a New Typology
(2019-03)Background: A key challenge for health systems harnessing digital tools and services is that of digital inclusion. Typically, digital inequalities are conceptualized in relation to unequal access or usage. However, these ... -
Childhood determinants of past-year anxiety and depression in recently transitioned military personnel
(2020-05)Background: Anxiety and depression may hamper a smooth transition from military to civilian life and may be important predictors of longer-term health and functioning. However, it is as yet unclear to what extent they are ... -
Childhood Maltreatment and Violent Outcomes: A Systematic Review and Meta-Analysis of Prospective Studies
(2018-08)The risk of violence following childhood maltreatment is uncertain. This meta-analytic review identified prospective studies that have examined this association. We systematically searched three electronic databases ... -
Children and Young people with Avoidant Restrictive Food Intake Disorder (ARFID)
(2023-11)Avoidant/Restrictive Food Intake Disorder (ARFID) was introduced as a new mental health and behaviour disorder diagnosis in 2013. ARFID is characterised by a pattern of eating that avoids certain foods or food groups ... -
Choking Phobia in an Older Adult: A Telephone-Based CBT Case Study Informed by Gerontology
(2022-06)Fear of choking is a relatively understudied phenomenon in older adults, despite the higher incidence of choking to death in this population and the associated mental health burden. This case report presents the use of a ... -
Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity.
(2018-12-17)Psychosocial stressors including childhood adversity, migration, and living in an urban environment, have been associated with several psychiatric disorders, including psychotic disorders. The neural and psychological ... -
Clients' experience of change: an exploration of the influence of reformulation tools in Cognitive Analytic Therapy
(2018-10-10)Case formulation is considered important in both the development of the therapeutic relationship and in starting the process of therapeutic change. Cognitive analytic therapy describes the developmental origins and maintenance ... -
Clinical prediction tools to identify patients at highest risk of myeloma in primary care: a retrospective open cohort study
(2021-04)Background Patients with myeloma experience substantial delays in their diagnosis, which can adversely affect their prognosis. Aim To generate a clinical prediction rule to identify primary care patients who are at highest ... -
Clinical Prompt Learning with Frozen Language Models
(2022-05)Prompt learning is a new paradigm in the Natural Language Processing (NLP) field which has shown impressive performance on a number of natural language tasks with common benchmarking text datasets in full, few-shot, and ... -
Clinical- and cost-effectiveness of a technology-supported and solution-focused intervention (DIALOG+) in treatment of patients with chronic depression—study protocol for a multi-site, cluster randomised controlled trial [TACK]
(2022-03)Many with an acute depressive disorder go on to develop chronic depression, despite ongoing care. There are few specifically designed interventions to treat chronic depression. DIALOG+, a technology-assisted intervention ... -
Clinician barriers and facilitators to heart failure advance care plans: a systematic literature review and qualitative evidence synthesis
(2019-07)Background:Clinicians hesitate to engage with advance care planning (ACP) in heart failure. We aimed to identify the disease-specific barriers and facilitators for clinicians to engage with ACP. Methods: We searched ... -
Clinician-targeted interventions to improve advance care planning in heart failure: a systematic review and meta-analysis
(2019-05)Objective Advance care planning (ACP) is widely advocated to contribute to better outcomes for patients suffering from heart failure. But clinicians appear hesitant to engage with ACP. Our aim was to identify interventions ... -
Clinicians’ use of and attitudes towards technology to provide and support interventions in child and adolescent mental health services
(2019-12)Background:Technology can increase child and adolescent mental health service (CAMHS) capacity by sup-porting and delivering interventions, yet it has not been widely adopted by CAMHS child mental health professionals. ... -
Clinicians’ views of treatment types for first episode psychosis delivered in a randomised controlled trial (MAPS)
(2020-07)Background Clinicians’ treatment beliefs could affect the feasibility of delivering different treatments in a randomised controlled trial (RCT). In MAPS (Managing Adolescent first Episode Psychosis: a feasibility Study), ... -
Clozapine and Sweet's syndrome: case report
(2023-09)A patient developed fever, raised inflammatory markers and a maculopapular rash following commencement of clozapine for treatment of his schizoaffective disorder. Skin biopsy confirmed Sweet's syndrome. Identification of ... -
Clozapine-induced pericarditis: an ethical dilemma
(2019-06)Clozapine is an atypical antipsychotic used most frequently in the management of treatment-resistant schizophrenia, where severely unwell patients have failed to respond to standard antipsychotic therapy. Clozapine is ... -
A co-produced online cultural experience compared to a typical museum website for mental health in people aged 16-24: A proof-of-principle randomised controlled trial
(2022-09)Objective: We aimed to compare a co-produced online intervention encompassing the diverse human stories behind art and artefacts, named Ways of Being (WoB), with a typical museum website, the Ashmolean (Ash) on negative ... -
Cognition in Mood Disorders
(2020-01)Mood disorders are common, complex, and one of the main causes of morbidity worldwide (1). There has been an increasing recognition that cognitive dysfunction is a central aspect of most mood disorders, as well as being ...