Browsing by Author "Tunbridge, Elizabeth"
Now showing items 1-16 of 16
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CACNA1C (CaV1.2) and other L-type calcium channels in the pathophysiology and treatment of psychiatric disorders: Advances from functional genomics and pharmacoepidemiology
Harrison, Paul J; Colbourne, Lucy; Mould, Arne; Tunbridge, Elizabeth (2022-09)A role for voltage-gated calcium channels (VGCCs) in psychiatric disorders has long been postulated as part of a broader involvement of intracellular calcium signalling. However, the data were inconclusive and hard to ... -
Catechol-O-methyltransferase activity does not influence emotional processing in men
Martens, M A G; Scaife, Jessica; Harmer, Catherine J; Harrison, Paul J; Tunbridge, Elizabeth (2022-04)Background: Catechol-O-methyltransferase (COMT) regulates cortical dopaminergic transmission and prefrontal-dependent cognitive function. However, its role in other cognitive processes, including emotional processing, is ... -
Dopaminergic modulation of regional cerebral blood flow: An arterial spin labelling study of genetic and pharmacological manipulation of COMT activity
Martens, M A G; Philippini, N; Harrison, Paul J; Tunbridge, Elizabeth; Mackay, Clare (2021-07)Dopamine has direct and complex vasoactive effects on cerebral circulation. Catechol-O-methyltransferase (COMT) regulates cortical dopamine, and its activity can be influenced both genetically and pharmacologically. COMT ... -
Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression
Tunbridge, Elizabeth; Harrison, Paul J (2018)Risk-taking behaviour is an important component of several psychiatric disorders, including attention-deficit hyperactivity disorder, schizophrenia and bipolar disorder. Previously, two genetic loci have been associated ... -
The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function
Tunbridge, Elizabeth; Harrison, Paul J (2019)Genome-wide association studies (GWAS) of psychiatric phenotypes have tended to focus on categorical diagnoses, but to understand the biology of mental illness it may be more useful to study traits which cut across traditional ... -
Induced pluripotent stem cells in psychiatry: a critical review
De Los Angeles, Alejandro; Hall, Nicola A; Harrison, Paul J; Tunbridge, Elizabeth (2021-01)A key challenge in psychiatry research is the development of high-fidelity model systems that can be experimentally manipulated to explore and test pathophysiological mechanisms of illness. In this respect, the emerging ... -
Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia
Mould, Arne; Al-Juffali, Noura; Tunbridge, Elizabeth (2021-12)The cognitive dysfunction experienced by patients with schizophrenia represents a major unmet clinical need. We believe that enhancing synaptic function and plasticity by targeting kalirin may provide a novel means to ... -
Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes
Mould, Arne; De Los Angeles, Alejandro; Tunbridge, Elizabeth (2021-04)Alternative splicing (AS) is a key mechanism underlying cellular differentiation and a driver of complexity in mammalian neuronal tissues. However, understanding of which isoforms are differentially used or expressed and ... -
New drug targets in psychiatry: Neurobiological considerations in the genomics era
Harrison, Paul J; Mould, Arne; Tunbridge, Elizabeth (2022-07)After a period of withdrawal, pharmaceutical companies have begun to reinvest in neuropsychiatric disorders, due to improvements in our understanding of these disorders, stimulated in part by genomic studies. However, ... -
The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study
Atkinson, Lauren Z; Colbourne, Lucy; Smith, Alexander L W; Harmer, Catherine J; Nobre, Anna C; Rendell, Jennifer; Jones, Helen; Hinds, Christopher; Mould, Arne; Tunbridge, Elizabeth; Cipriani, Andrea (2019-02)Background: The discovery that voltage-gated calcium channel genes such as CACNA1C are part of the aetiology of psychiatric disorders has rekindled interest in the therapeutic potential of L-type calcium channel (LTCC) ... -
Plasma glutathione suggests oxidative stress is equally present in early- and late- onset bipolar disorder
Singh, Nisha; McMahon, Hannah; Bilderbeck, Amy; Reed, Zoe E; Tunbridge, Elizabeth; Brett, Daniel; Geddes, John R; Goodwin, Guy M (2018-03)We previously demonstrated oxidative stress in bipolar patients and a relationship between the age of illness onset and total glutathione, a principal antioxi- dant. In this study, we sought to replicate these findings ... -
Roadblock: improved annotations do not necessarily translate into new functional insights
Hall, Nicola A; Tunbridge, Elizabeth (2021-11)The advent of cost-effective high-throughput nucleotide sequencing means that information about the transcriptome is accruing at an exponential rate, rapidly refining our understanding of the diversity of gene products. ... -
Targeting synaptic plasticity in schizophrenia: insights from genomic studies
Hall, Nicola A; Tunbridge, Elizabeth (2021-08)Recent genomic findings identify many hundreds of genomic loci that are associated with schizophrenia. Consistent with data from the pregenomic era, genomic findings implicate synaptic function and plasticity as a tractable ... -
Unraveling Mechanisms of Patient-Specific NRXN1 Mutations in Neuropsychiatric Diseases Using Human Induced Pluripotent Stem Cells
Tunbridge, Elizabeth (2020-03)Rare heterozygous deletions in the neurexin 1 (NRXN1) gene robustly increase an individual's risk of developing neurological and psychiatric disorders. However, the molecular bases by which different mutations result in ... -
Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal
Harrison, Paul J; Tunbridge, Elizabeth (2019-06)We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and ... -
Which Dopamine Polymorphisms are Functional? Systematic Review and Meta-Analysis of COMT, DAT, DBH, DDC, DRD1-5, MAOA, MAOB, TH, VMAT1 and VMAT2
Tunbridge, Elizabeth; Cipriani, Andrea; Harrison, Paul J (2019-05)BACKGROUND: Many polymorphisms in dopamine genes are reported to affect cognitive, imaging or clinical phenotypes. It is often inferred or assumed that such associations are causal, mediated by a direct effect of the ...