Browsing by Author "Murphy, Susannah E"
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Acute neural effects of fluoxetine on emotional regulation in depressed adolescents
Capitao, Liliana; Chapman, Robert; Wright, Lucy C; Murphy, Susannah E; James, Anthony; Cowen, Philip J; Harmer, Catherine J (2022-05)Adolescent major depressive disorder (MDD) is associated with disrupted processing of emotional stimuli and difficulties in cognitive reappraisal. Little is known however about how current pharmacotherapies act to modulate ... -
APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review
Murphy, Susannah E (2018-07)APOE-ε4 is best known as a risk factor for Alzheimer's disease (AD). Consequently, there is considerable research interest in understanding whether APOE-ε4 influences cognition in healthy adults. Despite a substantial ... -
Déjà-vu? Neural and behavioural effects of the 5-HT 4 receptor agonist, prucalopride, in a hippocampal-dependent memory task
De Cates, Angharad N; Wright, Lucy C; Gibson, Daisy; Cowen, Philip J; Harmer, Catherine J; Murphy, Susannah E (2021-10)Cognitive deficits commonly accompany psychiatric disorders but are often underrecognised, and difficult to treat. The 5-HT4 receptor is a promising potential treatment target for cognitive impairment because in animal ... -
Effect of acute citalopram on self-referential emotional processing and social cognition in healthy volunteers
Murphy, Susannah E; Wright, Lucy C; Carson, James; Van Assche, Indra; O'Brien, Jessica; Oyesanya, Mayowa; Harmer, Catherine J (2020-10)Background Depression is characterised by negative views of the self. Antidepressant treatment may remediate negative self-schema through increasing processing of positive information about the self. Changes in affective ... -
How representative are neuroimaging samples? Large-scale evidence for trait anxiety differences between MRI and behaviour-only research participants.
Pulcu, Erdem; Murphy, Susannah E; Kaltenboeck, Alexander; Browning, Michael; Harmer, Catherine J (2020-04)Over the past three decades, MRI has become a key tool to study how cognitive processes are implemented in the human brain. However, the question of whether participants recruited into MRI studies differ from participants ... -
The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action
Murphy, Susannah E; Capitao, Liliana; Cowen, Philip J; Harmer, Catherine J (2021-08)The use of SSRIs for the treatment of depression and anxiety in young people is increasing. However, the effects of SSRIs in adolescence, a time when there are substantial changes in neural, cognitive, and social functioning, ... -
Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
Capitao, Liliana; Chapman, Robert; Wright, Lucy C; Murphy, Susannah E; James, Anthony; Cowen, Philip J; Harmer, Catherine J (2020-11)Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the ... -
A single dose of fluoxetine reduces neural limbic responses to anger in depressed adolescents
Capitao, Liliana; Chapman, Robert; Murphy, Susannah E; James, Anthony; Cowen, Philip J; Harmer, Catherine J (2019-01-21)Depression in adolescence is frequently characterised by symptoms of irritability. Fluoxetine is the antidepressant with the most favourable benefit:risk ratio profile to treat adolescent depression, but the neural ... -
Translating the promise of 5HT4 receptor agonists for the treatment of depression
Murphy, Susannah E; De Cates, Angharad N; Gillespie, Amy L; Godlewska, Beata R; Scaife, Jessica; Wright, Lucy C; Cowen, Philip J; Harmer, Catherine J (2020-02)Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are postsynaptic receptors that are located in ...