Browsing by Author "Geddes, John R"
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Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization
Taquet, Maxime; Geddes, John R; Harrison, Paul J (2023-08)Post-COVID cognitive deficits, including 'brain fog', are clinically complex, with both objective and subjective components. They are common and debilitating, and can affect the ability to work, yet their biological ... -
Adjunctive Psychotherapy for Bipolar Disorder A Systematic Review and Component Network Meta-analysis
Geddes, John R; Cipriani, Andrea (2020-10)Importance Several psychotherapy protocols have been evaluated as adjuncts to pharmacotherapy for patients with bipolar disorder, but little is known about their comparative effectiveness. Objective To use systematic ... -
Antidepressants might work for people with major depression: where do we go from here? (Comment)
Cipriani, Andrea; Geddes, John R (2018-06)The publication of our updated network meta-analysis about antidepressants for the acute treatment of major depression has generated a wide discussion in newspapers, social media, and scientific journals. Based on 522 ... -
Association between serum lithium level and incidence of COVID-19 infection
Geddes, John R (2022-03)An antiviral effect of lithium has been proposed, but never investigated for coronavirus disease 2019 (COVID-19). Using electronic health records of 26 554 patients with documented serum lithium levels during the pandemic, ... -
Association of Schizophrenia Spectrum Disorders and Violence Perpetration in Adults and Adolescents From 15 Countries A Systematic Review and Meta-analysis
Geddes, John R; Fazel, Seena; Whiting, Daniel; Gulati, Gautam (2021-12)Violence perpetration outcomes in individuals with schizophrenia spectrum disorders contribute to morbidity and mortality at a population level, disrupt care, and lead to stigma. Objective : To conduct a systematic ... -
Automated virtual reality (VR) cognitive therapy for patients with psychosis: study protocol for a single-blind parallel group randomised controlled trial (gameChange).
Freeman, Daniel; Lambe, Sinead; Rovira, Aitor; Goodsell, Andrew; Rosebrock, Laina; Geddes, John R; Clark, David M; Waite, Felicity (2019-08)Introduction Many patients with psychosis experience everyday social situations as anxiety-provoking. The fears can arise, for example, from paranoia, hallucinations, social anxiety or negative-self beliefs. The fears lead ... -
Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA
Taquet, Maxime; Geddes, John R; Harrison, Paul J (2020)Background Adverse mental health consequences of COVID-19, including anxiety and depression, have been widely predicted but not yet accurately measured. There are a range of physical health risk factors for COVID-19, but ... -
Cerebral venous thrombosis: a retrospective cohort study of 513,284 confirmed COVID-19 cases and a comparison with 489,871 people receiving a COVID-19 mRNA vaccine
Taquet, Maxime; Geddes, John R; Harrison, Paul J (2021-04)Objectives To estimate the absolute risk of cerebral venous thrombosis (CVT) and portal vein thrombosis (PVT) in the two weeks following a diagnosis of COVID-19, and to assess the relative risks (RR) compared to influenza ... -
Characterizing Affective Variability in Bipolar Disorder and Borderline Personality Disorder, and the Effects of Lithium, Using a Generative Model of Affect
Saunders, Kate E.A.; Harmer, Catherine J; Harrison, Paul J; Goodwin, Guy M; Geddes, John R; Browning, Michael (2022-02)The affective variability of Bipolar Disorder (BD) is thought to qualitatively differ from that of Borderline Personality Disorder (BPD), with changes in affect persisting for longer in BD. However, quantitative studies ... -
Clinical- and cost-effectiveness of a technology-supported and solution-focused intervention (DIALOG+) in treatment of patients with chronic depression—study protocol for a multi-site, cluster randomised controlled trial [TACK]
Molodynski, Andrew; Geddes, John R (2022-03)Many with an acute depressive disorder go on to develop chronic depression, despite ongoing care. There are few specifically designed interventions to treat chronic depression. DIALOG+, a technology-assisted intervention ... -
A co-produced online cultural experience compared to a typical museum website for mental health in people aged 16-24: A proof-of-principle randomised controlled trial
Sheriff, Rebecca Syed; Harmer, Catherine J; Geddes, John R (2022-09)Objective: We aimed to compare a co-produced online intervention encompassing the diverse human stories behind art and artefacts, named Ways of Being (WoB), with a typical museum website, the Ashmolean (Ash) on negative ... -
Comparative economic evaluation of quetiapine plus lamotrigine combination vs quetiapine monotherapy (and folic acid vs placebo) in patients with bipolar depression (cequel)
Geddes, John R; Gardiner, Alexandra; Rendell, Jennifer; Goodwin, Guy M; Simon, Judit (2018-12)Although not licensed for acute bipolar depression, lamotrigine has evidence for efficacy in trials and its use is recommended in guidelines. So far there had been no prospective health economic evaluation of its use. ... -
Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis
Cipriani, Andrea; Geddes, John R (2018-04)BACKGROUND Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological treatments are available; however, because of ... -
Comparative efficacy and acceptability of antidepressants in the long-term treatment of major depression: protocol for a systematic review and networkmeta-analysis
Geddes, John R; Cipriani, Andrea (2019-05)Introduction: Pharmacotherapy plays an important role in the treatment of major depression. At the initiation of antidepressant treatment, both improvement of symptoms in the short term and relapse prevention in the long ... -
Consent to discuss participation in research: a pilot study
Potts, Jennifer; Barrera, Alvaro; Hancock, Mark; Bell, Stuart; Cipriani, Andrea; Geddes, John R; Henshall, Catherine (2019-09)Background. Equitable access to research studies needs to be increased for all patients. There is debate about which is the best approach to use to discuss participation in research in real-world clinical settings. Objective. ... -
The costs of bipolar disorder in the United Kingdom
Simon, Judit; Goodwin, Guy M; Geddes, John R (2021-09)Objectives: To estimate the individual cost and population-level economic burden of Bipolar Disorder (BD), and explore the impact of clinical and sociodemographic factors on costs in the United Kingdom. Methods: Annual ... -
Disrupting the power balance between doctors and patients in the digital era
Geddes, John R (2021-01)The primary way of identifying symptoms of impending disease, and when it is time to seek care, relies heavily on a patient's own perception of how they feel. This reliance on a disease reaching a threshold at which ... -
Effect of lithium on circadian rhythm in bipolar disorder: A systematic review and meta-analysis
Saunders, Kate E.A.; Cipriani, Andrea; Geddes, John R (2021-03)Circadian rhythm disruption is commonly reported in patients with bipolar disorder. Lithium has been suggested to have effects on the circadian clock, the biological basis of the circadian rhythm. The objective of the ... -
Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: A systematic review of evidence from observational studies
Geddes, John R; Goodwin, Guy M (2018-02)Objectives: For the first time to present a systematic review of observational studies on the efficiency of lithium monotherapy in comparison with other maintenance mood stabilizers in monotherapy and in combination. Methods: ... -
Ethical challenges in Research, Industry and People Partnerships in mental health
Geddes, John R (2020-08)Advancements in mental health research, social changes and policy developments have led to the emergence of new forms of research partnerships, which bring together research institutions, public companies and lay people ...