Browsing by Author "Geddes, John R"
Now showing items 21-40 of 44
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Experiences of remote mood and activity monitoring in bipolar disorder: a qualitative study
Saunders, Kate E.A.; Geddes, John R; Goodwin, Guy M (2017-01)Mobile technology enables high frequency mood monitoring and automated passive collection of date(e.g.actigraphy) from patients more efficiently and less intrusively than has previously been possible. Such techniques are ... -
How pharmacist prescribers can help meet the mental health consequences of COVID-19
Macdonald, Orla; Smith, Katharine A; Marven, Michael; Broughton, Nick; Geddes, John R; Cipriani, Andrea (2020-11)We suggest that Mental Health Trusts should urgently develop prescribing roles for specialist mental health pharmacists, which are integrated within mental health teams. In these roles, prescribing pharmacists can ... -
Incidence and outcomes of eating disorders during the COVID-19 pandemic
Taquet, Maxime; Harrison, Paul J; Geddes, John R (2021-07)There are concerns that eating disorders have become commoner during the coronavirus disease 2019 (COVID-19) pandemic. Using the electronic health records of 5.2 million people aged under 30, mostly in the USA, we show ... -
Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19
Taquet, Maxime; Geddes, John R; Harrison, Paul J (2021-09)Long-COVID refers to a variety of symptoms affecting different organs reported by people following Coronavirus Disease 2019 (COVID-19) infection. To date, there have been no robust estimates of the incidence and co-occurrence ... -
Informing National Health Service patients about participation in clinical research: A comparison of opt-in and opt-out approaches across the United Kingdom
Cipriani, Andrea; Henshall, Catherine; Potts, Jennifer; Hancock, Mark; Underwood, Mark; Broughton, Nick; Ede, Roger; Kernot, Catherine; O'Neill, Lorcan; Geddes, John R (2020-11)Objective: Recruitment to clinical research in the National Health Service remains challenging. One barrier is accessing patients to discuss research participation. Two general approaches are used in the United Kingdom ... -
Introducing artificial intelligence in acute psychiatric inpatient care: qualitative study of its use to conduct nursing observations.
Barrera, Alvaro; Gee, Carol; Wood, Andrew; Geddes, John R (2020-02)Background All patients admitted to an acute inpatient mental health unit must have nursing observations carried out at night either hourly or every 15 minutes, to ascertain that they are safe and breathing. However, while ... -
Melatonin In Acute Mania Investigation (MIAMI‐UK). A randomised controlled trial of add‐on melatonin in bipolar disorder
Quested, Digby J; Simpson, Jessica C; Cordey, Julia H; Economou, Alexis; De Crescenzo, Franco; Lawson, Jennifer; Al-Taiar, Hasanen; Lennox, Alison; Geddes, John R (2020-05)Objectives Current options for treating emergent episodes of hypomania and mania in bipolar disorder are limited. Our objective was to compare the effectiveness and safety of add‐on melatonin in hypomania or mania over ... -
Mental health prior to and during the COVID-19 pandemic in individuals with bipolar disorder: Insights from prospective longitudinal data
Saunders, Kate E.A.; South, Matthew; Geddes, John R (2022-03)Many studies have examined the impact of COVID-19 on the mental health of the public, but few have focused on individuals with existing severe mental illness with longitudinal data before and during the pandemic. Aims: To ... -
Mixed effects approach to the analysis of the stepped wedge cluster randomised trial—Investigating the confounding effect of time through simulation
Geddes, John R (2018-12)A stepped wedge cluster randomised trial (SWCRT) is a multicentred study which allows an intervention to be rolled out at sites in a random order. Once the intervention is initiated at a site, all participants within that ... -
A narrative review of the success of intramuscular gluteal injections and its impact in psychiatry
Gee, Carol; Harker, Aidan; Barrera, Alvaro; Geddes, John R (2018-07)There are 12 billion injections given worldwide every year. For many injections, the intramuscular route is favoured over the subcutaneous route due to the increased vascularity of muscle tissue and the corresponding ... -
Network meta-analysis of antidepressants – Authors' reply
Cipriani, Andrea; Geddes, John R (2018-09-22)Comments on issues raised with Cipriani et al, 'Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis' ... -
Online mood monitoring in treatment-resistant depression: qualitative study of patients' perspectives in the NHS
Geddes, John R (2020-01)Aims and method True Colours is an automated symptom monitoring programme used by National Health Service psychiatric services. This study explored whether patients with unipolar treatment-resistant depression (TRD) found ... -
Plasma glutathione suggests oxidative stress is equally present in early- and late- onset bipolar disorder
Singh, Nisha; McMahon, Hannah; Bilderbeck, Amy; Reed, Zoe E; Tunbridge, Elizabeth; Brett, Daniel; Geddes, John R; Goodwin, Guy M (2018-03)We previously demonstrated oxidative stress in bipolar patients and a relationship between the age of illness onset and total glutathione, a principal antioxi- dant. In this study, we sought to replicate these findings ... -
Pramipexole Enhances Reward Learning by Preserving Value Estimates
Halahakoon, Don Chamith; Geddes, John R; Cowen, Philip J; Harmer, Catherine J; Browning, Michael (2022-01)Background: Dopamine D2-like receptor agonists show promise as treatments for depression. They are thought to act by altering how individuals learn from rewarding experiences. However, the nature of these reward learning ... -
Psychosocial markers of age at onset in bipolar disorder: a machine learning approach
Joyce, Dan W; Geddes, John R; Saunders, Kate E.A. (2022-07)Bipolar disorder is a chronic and severe mental health disorder. Early stratification of individuals into subgroups based on age at onset (AAO) has the potential to inform diagnosis and early intervention. Yet, the ... -
A retrospective examination of care pathways in individuals with treatment-resistant depression
Harvey, Jade; Geddes, John R; Barrera, Alvaro (2021-05)Individuals with treatment-resistant depression (TRD) experience a high burden of illness. Current guidelines recommend a stepped care approach for treating depression, but the extent to which best-practice care pathways ... -
A signature-based machine learning model for distinguishing bipolar disorder and borderline personality disorder
Goodwin, Guy M; Geddes, John R; Saunders, Kate E.A. (2018)Mobile technologies offer new opportunities for prospective, high resolution monitoring of long-term health conditions. The opportunities seem of particular promise in psychiatry where diagnoses often rely on retrospective and ... -
Six-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19
Taquet, Maxime; Geddes, John R; Harrison, Paul J (2021-01)Background. Neurological and psychiatric sequelae of COVID-19 have been reported, but there are limited data on incidence rates and relative risks. Methods. Using retrospective cohort studies and time-to-event analysis, ... -
Sleep deprivation as a treatment for major depressive episodes: A systematic review and meta-analysis
Mitter, Pamina; Geddes, John R; Cipriani, Andrea (2022-05)Sleep deprivation, alone or in combination with pharmacological treatment and as part of a chronotherapy package, is of potential use for people with major depressive episodes, however the evidence base is still conflicting. ... -
Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)
Geddes, John R (2021-07)Treatment Resistant Bipolar Depression (TRBD) is a major contributor to the burden of disease associated with Bipolar Disorder (BD). Treatment options for people experiencing bipolar depression are limited to three ...