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Mixed effects approach to the analysis of the stepped wedge cluster randomised trial—Investigating the confounding effect of time through simulation
(2018-12)
A stepped wedge cluster randomised trial (SWCRT) is a multicentred study which allows an intervention to be rolled out at sites in a random order. Once the intervention is initiated at a site, all participants within that ...
Network meta-analysis of antidepressants – Authors' reply
(2018-09-22)
Comments on issues raised with Cipriani et al, 'Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis' ...
Successful recruitment to trials: findings from the SCIMITAR+ Trial
(2018-01-19)
Background:
Randomised controlled trials (RCT) can struggle to recruit to target on time. This is especially the case with hard to reach populations such as those with severe mental ill health. The SCIMITAR+ trial, a trial ...
Patient and public involvement in reducing health and care research waste
(2018-01-08)
Background: Eighty five per cent of health research expenditure is potentially wasted due to failure to publish research, unclear reporting of research that is published, and the failure of new research studies to ...
Living network meta-analysis compared with pairwise meta-analysis in comparative effectiveness research: empirical study
(2018-02-28)
Objective:To examine whether the continuous updating of networks of prospectively planned randomised controlled trials (RCTs) (“living” network meta-analysis) provides strong evidence against the null hypothesis in comparative ...
Adding value, reducing research waste, the role of the NHS research and development management community
(2018-02-23)
Purpose – Research suggests that 85 per cent of health research is avoidably wasted. The research and
development management community has an important role in the research process and can contribute to
improving the ...
Sham sleep feedback delivered via actigraphy biases daytime symptom reports in people with insomnia: Implications for insomnia disorder and wearable devices
(2018-07)
This study investigated whether providing sham feedback about sleep to individuals with insomnia influenced daytime symptom reports, sleep‐related attentional bias and psychomotor vigilance. Sixty‐three participants meeting ...
Impact of placebo arms on outcomes in antidepressant trials: systematic review and meta-regression analysis
(2018-06)
There is debate in the literature as to whether inclusion of a placebo arm may alter characteristics of antidepressant trials. However, previous research has focused on response rates of various antidepressants on average ...
Can rapid approaches to qualitative analysis deliver timely, valid findings to clinical leaders? A mixed methods study comparing rapid and thematic analysis
(2018-08)
Objectives: This study compares rapid and traditional
analyses of a UK health service evaluation dataset to
explore differences in researcher time and consistency of
outputs.
Design: Mixed methods study, quantitatively ...
Qualitative study of barriers to clinical trial retention in adults with recently diagnosed type 1 diabetes
(2018-07)
Objectives: Regular physical exercise may preserve β cell
function in newly diagnosed adults with type 1 diabetes
(T1D). However, clinical trials to test this theory require the
recruitment and retention of adults with ...