Browsing by Author "Quested, Digby J"
Now showing items 1-4 of 4
-
Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
De Crescenzo, Franco; Ostinelli, Edoardo; Kurtulmus, Ayse; Tomlinson, Anneka; Quested, Digby J; Cowen, Philip J; Efthimiou, Orestis; Cipriani, Andrea (2022-07)Background: Behavioural, cognitive, and pharmacological interventions can all be effective for insomnia. However, because of inadequate resources, medications are more frequently used worldwide. We aimed to estimate the ... -
Melatonin In Acute Mania Investigation (MIAMI‐UK). A randomised controlled trial of add‐on melatonin in bipolar disorder
Quested, Digby J; Simpson, Jessica C; Cordey, Julia H; Economou, Alexis; De Crescenzo, Franco; Lawson, Jennifer; Al-Taiar, Hasanen; Lennox, Alison; Geddes, John R (2020-05)Objectives Current options for treating emergent episodes of hypomania and mania in bipolar disorder are limited. Our objective was to compare the effectiveness and safety of add‐on melatonin in hypomania or mania over ... -
Overlap in genetic risk for cross-disorder vulnerability to mental disorders and genetic risk for altered subcortical brain volumes
Quested, Digby J (2021-01)Background: There have been considerable recent advances in understanding the genetic architecture of psychiatric disorders as well as the underlying neurocircuitry. However, there is little work on the concordance of genetic ... -
Rare coding variants in ten genes confer substantial risk for schizophrenia
Quested, Digby J (2022-04)Rare coding variation has historically provided the most direct connections between gene function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 schizophrenia cases and 97,322 controls, we implicate ...