Browsing by Author "Ostinelli, Edoardo"
Now showing items 1-16 of 16
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Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
De Crescenzo, Franco; Ostinelli, Edoardo; Kurtulmus, Ayse; Tomlinson, Anneka; Quested, Digby J; Cowen, Philip J; Efthimiou, Orestis; Cipriani, Andrea (2022-07)Background: Behavioural, cognitive, and pharmacological interventions can all be effective for insomnia. However, because of inadequate resources, medications are more frequently used worldwide. We aimed to estimate the ... -
Covid-19 and mental health: a transformational opportunity to apply an evidence-based approach to clinical practice and research
Smith, Katharine A; Ostinelli, Edoardo; Cipriani, Andrea (2020-04)The Oxford Precision Psychiatry Lab (https://oxfordhealthbrc.nihr.ac.uk/our-work/oxppl/, @OxfordPPL) collected from senior clinicians in the local Mental Health Trust a list of specific and focused questions about mental ... -
COVID-19 and substance use disorders: a review of international guidelines for frontline healthcare workers of addiction services
Ostinelli, Edoardo; Smith, Katharine A; Zangani, Caroline; Macdonald, Orla; Cipriani, Andrea (2022-03)People with substance use disorders may be at a greater risk of contracting COVID-19 infection and developing medical complications. Several institutional and governmental health agencies across the world developed ad hoc ... -
Development and validation of a meta-learner for combining statistical and machine learning prediction models in individuals with depression
De Crescenzo, Franco; Ostinelli, Edoardo; Tomlinson, Anneka; Cipriani, Andrea (2022-05)The debate of whether machine learning models offer advantages over standard statistical methods when making predictions is ongoing. We discuss the use of a meta-learner model combining both approaches as an alternative. ... -
Efficacy of tiapride in the treatment of psychiatric disorders: A systematic review
Zangani, Caroline; Ostinelli, Edoardo (2022-03)Tiapride is an atypical antipsychotic used to treat alcohol withdrawal, aggressiveness and agitation, headache, dyskinesias, tic and Tourette's disorder. More recently, it has been proposed for the treatment of delirium ... -
Examining the Effectiveness of Web-Based Interventions to Enhance Resilience in Health Care Professionals: Systematic Review
Henshall, Catherine; Ostinelli, Edoardo; Harvey, Jade; Cipriani, Andrea; Attenburrow, Mary-Jane (2022-07)Background: Internationally, the impact of continued exposure to workplace environmental and psychological stressors on health care professionals’mental health is associated with increased depression, substance misuse, ... -
Initial treatment choices to achieve sustained response in major depression: a systematic review and network meta-analysis
Cipriani, Andrea; Ostinelli, Edoardo (2021-10)Major depression is often a relapsing disorder. It is therefore important to start its treatment with therapies that maximize the chance of not only getting the patients well but also keeping them well. We examined the ... -
Knowledge and Use of Novel Psychoactive Substances in Italy: a Survey-Based Study in the General Population
Ostinelli, Edoardo (2021-11)In this study, we aimed to identify the current trend of novel psychoactive substance (NPS) consumption in Italy and the level of knowledge about NPS in the general population and to explore the presence of risk factors ... -
Off–label long acting injectable antipsychotics in real–world clinical practice: a cross-sectional analysis of prescriptive patterns from the STAR Network DEPOT study
Ostinelli, Edoardo; Zangani, Caroline (2022-06)Introduction Information on the off–label use of Long–Acting Injectable (LAI) antipsychotics in the real world is lacking. In this study, we aimed to identify the sociodemographic and clinical features of patients treated ... -
Optimal dose of brexpiprazole for augmentation therapy of antidepressant-refractory depression: A systematic review and dose-effect meta-analysis
Ostinelli, Edoardo (2022-06)Background: Brexpiprazole augmentation is an effective treatment strategy for antidepressant-refractory depression, but its optimal dosage remains unclear. Aims: To find the optimal dosage of brexpiprazole as augmentation ... -
Pro-dopaminergic pharmacological interventions for anhedonia in depression: protocol for a living systematic review of human and non-human studies
Ostinelli, Edoardo; Browning, Michael; Cipriani, Andrea; Harmer, Catherine J (2023-10)Anhedonia is a key symptom of depression, and it has been suggested as a potential target for future individualised treatments. However, much is unknown about how interventions enhancing dopaminergic pathways may affect ... -
Safety of 80 antidepressants, antipsychotics, anti-attention-deficit/ hyperactivity medications and mood stabilizers in children and adolescents with psychiatric disorders: a large scale systematic meta-review of 78 adverse effects
Ostinelli, Edoardo (2020-06)Mental disorders frequently begin in childhood or adolescence. Psychotropic medications have various indications for the treatment of mental disorders in this age group and are used not infrequently off‐label. However, ... -
Substance use disorder treatment success: assessing patient-reported use improvement and provider-evaluated treatment completion
Ostinelli, Edoardo (2021-11)Provider-evaluated substance use treatment completion and client-reported substance use improvement are standards in determining treatment success. The relationship between these two outcomes is anecdotally understood in ... -
Towards precision in the diagnostic profiling of patients: leveraging symptom dynamics in the assessment of major depressive disorder
Ostinelli, Edoardo; Cipriani, Andrea (2023-08)Major depressive disorder (MDD) is a heterogeneous mental disorder. International guidelines present overall symptom severity as the key dimension for clinical characterisation. However, additional layers of individual ... -
Trace amine-associated receptor 1 (TAAR1) agonists for psychosis: protocol for a living systematic review and meta-analysis of human and non-human studies.
Ostinelli, Edoardo; Cipriani, Andrea (2023-08)Background: There is an urgent need to develop more effective and safer antipsychotics beyond dopamine 2 receptor antagonists. An emerging and promising approach is TAAR1 agonism. Therefore, we will conduct a living ... -
Vitruvian plot: a visualisation tool for multiple outcomes in network meta-analysis
Ostinelli, Edoardo; Zangani, Caroline; Smith, Katharine A; Cipriani, Andrea (2022-05)Objective A network meta-analysis (NMA) usually assesses multiple outcomes across several treatment comparisons. The Vitruvian plot aims to facilitate communication of multiple outcomes from NMAs to patients and ...