Browsing by Author "Mould, Arne"
Now showing items 1-5 of 5
-
CACNA1C (CaV1.2) and other L-type calcium channels in the pathophysiology and treatment of psychiatric disorders: Advances from functional genomics and pharmacoepidemiology
Harrison, Paul J; Colbourne, Lucy; Mould, Arne; Tunbridge, Elizabeth (2022-09)A role for voltage-gated calcium channels (VGCCs) in psychiatric disorders has long been postulated as part of a broader involvement of intracellular calcium signalling. However, the data were inconclusive and hard to ... -
Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia
Mould, Arne; Al-Juffali, Noura; Tunbridge, Elizabeth (2021-12)The cognitive dysfunction experienced by patients with schizophrenia represents a major unmet clinical need. We believe that enhancing synaptic function and plasticity by targeting kalirin may provide a novel means to ... -
Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes
Mould, Arne; De Los Angeles, Alejandro; Tunbridge, Elizabeth (2021-04)Alternative splicing (AS) is a key mechanism underlying cellular differentiation and a driver of complexity in mammalian neuronal tissues. However, understanding of which isoforms are differentially used or expressed and ... -
New drug targets in psychiatry: Neurobiological considerations in the genomics era
Harrison, Paul J; Mould, Arne; Tunbridge, Elizabeth (2022-07)After a period of withdrawal, pharmaceutical companies have begun to reinvest in neuropsychiatric disorders, due to improvements in our understanding of these disorders, stimulated in part by genomic studies. However, ... -
The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study
Atkinson, Lauren Z; Colbourne, Lucy; Smith, Alexander L W; Harmer, Catherine J; Nobre, Anna C; Rendell, Jennifer; Jones, Helen; Hinds, Christopher; Mould, Arne; Tunbridge, Elizabeth; Cipriani, Andrea (2019-02)Background: The discovery that voltage-gated calcium channel genes such as CACNA1C are part of the aetiology of psychiatric disorders has rekindled interest in the therapeutic potential of L-type calcium channel (LTCC) ...