Browsing by Author "McCutcheon, Robert A"
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A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
Browning, Michael; Goodwin, Guy M; McCutcheon, Robert A; Cowen, Philip J (2023-06)A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why ... -
Relapse in clinically stable adult patients with schizophrenia or schizoaffective disorder: evidence-based criteria derived by equipercentile linking and diagnostic test accuracy meta-analysis
McCutcheon, Robert A (2023-11)Background: There is no consensus on defining relapse in schizophrenia, and scale-derived criteria with unclear clinical relevance are widely used. We aimed to develop an evidence-based scale-derived set of criteria to ... -
The relationship between striatal dopamine and anterior cingulate glutamate in first episode psychosis changes with antipsychotic treatment
McCutcheon, Robert A (2023-05)The neuromodulator dopamine and excitatory neurotransmitter glutamate have both been implicated in the pathogenesis of psychosis, and dopamine antagonists remain the predominant treatment for psychotic disorders. To date ... -
Shared and separate patterns in brain morphometry across transdiagnostic dimensions
McCutcheon, Robert A; Cipriani, Andrea (2023-01)Determining similarities and differences in brain structure across psychiatric disorders is important to determine if psychiatric taxonomy is reflected in distinct brain structural changes. As previous neuroimaging ...