Browsing by Author "Macdonald, Orla"
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COVID-19 and substance use disorders: a review of international guidelines for frontline healthcare workers of addiction services
Ostinelli, Edoardo; Smith, Katharine A; Zangani, Caroline; Macdonald, Orla; Cipriani, Andrea (2022-03)People with substance use disorders may be at a greater risk of contracting COVID-19 infection and developing medical complications. Several institutional and governmental health agencies across the world developed ad hoc ... -
Data-Driven Identification of Unusual Prescribing Behavior: Analysis and Use of an Interactive Data Tool Using 6 Months of Primary Care Data From 6500 Practices in England
Macdonald, Orla (2023-04)Background: Approaches to addressing unwarranted variation in health care service delivery have traditionally relied on the prospective identification of activities and outcomes, based on a hypothesis, with subsequent ... -
How pharmacist prescribers can help meet the mental health consequences of COVID-19
Macdonald, Orla; Smith, Katharine A; Marven, Michael; Broughton, Nick; Geddes, John R; Cipriani, Andrea (2020-11)We suggest that Mental Health Trusts should urgently develop prescribing roles for specialist mental health pharmacists, which are integrated within mental health teams. In these roles, prescribing pharmacists can ... -
Impact of the COVID-19 Pandemic on the Global Delivery of Mental Health Services and Telemental Health: Systematic Review
Macdonald, Orla; Reid, Katherine; Bale, Robert; Hawton, Keith; Cipriani, Andrea (2022-08)The COVID-19 pandemic required mental health services around the world to adapt quickly to the new restrictions and regulations put in place to reduce the risk of transmission. As face-to-face contact became difficult, ... -
Implementing a digital clinical decision support tool for side effects of antipsychotics: a focus group study
Henshall, Catherine; Cipriani, Andrea; Macdonald, Orla (2019-04-15)In medicine, algorithms can inform treatment decisions by combining the most up-to-date evidence about side effect profiles of medications, which are comparable in efficacy. Their use provides opportunities for improved ... -
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
Sharpley, Ann L; Williams, Clare; Holder, Adele A; Godlewska, Beata R; Macdonald, Orla; Cowen, Philip J (2020-09)Rationale Lithium is an effective prophylactic and anti-manic treatment in bipolar disorder; however, its use is declining through perceived poor tolerance and toxicity. Lithium inhibits inositol monophosphatase (IMPase), ...