Browsing by Author "Lennox, Belinda"
Now showing items 1-20 of 21
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25 On being autoimmune in psychiatric places: 10 characteristic mental state features in patients with definite NMDAR-antibody encephalitis
Lennox, Belinda; Critchlow, Gail (2019-05)Objectives/Aims: NMDAR-antibody encephalitis frequently presents with psychiatric symptoms. However, new-onset mental illness does not usually receive detailed biomedical investigations. Yet, early diagnosis and treatment ... -
Attitudes to physical healthcare in severe mental illness; a patient and mental health clinician qualitative interview study
De Cassan, Simone; Lennox, Belinda (2020-11)People with severe mental illness experience physical health significantly worse than the general population. Physical health monitoring is shared between primary care and secondary mental healthcare services, though there ... -
Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin
Lennox, Belinda (2019-10)There is increasing recognition in the neurological and psychiatric literature of patients with so-called isolated psychotic presentations (ie, with no, or minimal, neurological features) who have tested positive for ... -
Brain glutamate concentration in men with early psychosis: a magnetic resonance spectroscopy case–control study at 7 T
Godlewska, Beata R; Lennox, Belinda; Cowen, Philip J (2021-06)Abnormalities in glutamate neurotransmission are linked to psychotic symptoms and cognitive dysfunction in schizophrenia. magnetic resonance spectroscopy (MRS) provides an acceptable means of measuring glutamate in the ... -
Challenging the psychiatry–neurology divide: the case of autoimmune encephalitis
Lennox, Belinda (2022-03)A new case series describes a cohort of individuals with severe psychiatric presentations who were diagnosed with ‘possible’ or ‘probable’ autoimmune encephalitis on the basis of neurological examination. Many participants ... -
Discharge pathways and relapse following treatment from early intervention in psychosis services
Puntis, Stephen; Lennox, Belinda (2018-04)Early intervention in psychosis (EIP) services are the dominant service model in the treatment of first-episode psychosis. They are a time-limited intervention and little is known about discharge destinations and outcomes ... -
The early impact of the COVID-19 pandemic on patients with severe mental illness: An interrupted time-series study in South-East England
Lennox, Belinda; Hawton, Keith (2022-04)Abstract Background. Deterioration in general population mental health since the start of the COVID-19 pandemic has been reported, but the impact of the pandemic on people with severe mental illness (SMI) has received ... -
The Early Youth Engagement in first episode psychosis (EYE-2) study: pragmatic cluster randomised controlled trial of implementation, effectiveness and cost-effectiveness of a team-based motivational engagement intervention to improve engagement
Lennox, Belinda; Johns, Louise (2021-04)Background Early Intervention in Psychosis (EIP) services improve health outcomes for young people with psychosis in the medium–long term, but 25% of young people disengage in the first 12 months with costs to their mental ... -
The effect of a youth mental health service model on access to secondary mental healthcare for young people aged 14–25 years
Lennox, Belinda (2018-09)Aims and method The Norfolk Youth Service was created in 2012 in response to calls to redesign mental health services to better meet the needs of young people. The new service model transcends traditional boundaries by ... -
Effect of point of care blood testing on physical health check completion in mental health services: mixed-methods evaluation
De Cassan, Simone; Walton, Debbie; Bale, Robert; Lennox, Belinda (2020-10)Physical health outcomes in severe mental illness are worse than in the general population. Routine physical health check completion in this group is poor. Aims To quantitatively and qualitatively evaluate the impact of ... -
Elevated homocysteine and N-methyl-D-aspartate-receptor antibodies as a cause of behavioural and cognitive decline in 22q11.2 deletion syndrome
Banerjee, Subimal; Lennox, Belinda (2017-12)A 19-year-old male with 22q11.2 deletion syndrome presented with a 4-year history of cognitive decline and symptoms suggestive of atypical psychosis. Potential for elevated homocysteine and NMDA-receptor antibodies in the ... -
Endocannabinoid system mediates the association between gut-microbial diversity and anhedonia/amotivation in a general population cohort
Lennox, Belinda (2021-05)Anhedonia and amotivation are debilitating symptoms and represent unmet therapeutic needs in a range of clinical conditions. The gut-microbiome-endocannabinoid axis might represent a potential modifiable target for ... -
Enhancing psychological safety in mental health services
Lennox, Belinda; Vincent, Charles; Crofts, Marie; Hunt, David F; Bailey, Jill (2021-04)Background Psychological safety—speaking up about ideas and concerns, free from interpersonal risk—are essential to the high-risk environment, such as healthcare settings. Psychologically safe working is particularly ... -
Intravenous immunoglobulin and rituximab versus placebo treatment of antibody-associated psychosis: study protocol of a randomised phase IIa double-blinded placebo-controlled trial (SINAPPS2)
Lennox, Belinda; Yeeles, Ksenija; Tomei, Giuliano; Pollard, Rebecca; Vincent, Sally-Anne; Shimazaki, Mio (2019-06)Background: Evidence is conflicting about a causal role of inflammation in psychosis and, specifically, regarding antibodies binding to neuronal membrane targets, especially N-methyl-D-aspartate receptors. NMDAR, LGI1 and ... -
Measuring Disturbance of the Endocannabinoid System in Psychosis A Systematic Review and Meta-analysis
Cipriani, Andrea; Lennox, Belinda; Godlewska, Beata R (2019-06)Importance: The endocannabinoid system (ECS) is a lipid-based endogenous signaling system. Its relevance to psychosis is through the association between cannabis use and the onset and course of illness and through the ... -
Mental healthcare clinician engagement with point of care testing; a qualitative study
De Cassan, Simone; Lennox, Belinda (2021-02)Background Point of Care Testing (POCT) is being increasingly used to augment the delivery of physical health care in a variety of settings, but their use in mental health has been limited. Research into understanding the ... -
The psychological journey of weight gain in psychosis
Waite, Felicity; Langman-Levy, Amy; Mulhall, Sophie; Lennox, Belinda; Freeman, Daniel (2022-02)Rapid weight gain is common with antipsychotic medication. Lost confidence, low mood and medication non-adherence often follow. Yet, the dynamic interactions between the physical and psychological consequences of weight ... -
The psychopathology of NMDAR-antibody encephalitis in adults: a systematic review and phenotypic analysis of individual patient data
Lennox, Belinda; Harrison, Paul J (2019-03)Early immunotherapy administration improves outcomes in patients with N-methyl-D-aspartate receptor (NMDAR)-antibody encephalitis. As most patients with NMDAR-antibody encephalitis present to psychiatrists, the psychopathology ... -
The serum metabolomic profile of a distinct, inflammatory subtype of acute psychosis
Lennox, Belinda; Yeeles, Ksenija (2022-09)A range of studies suggest that a proportion of psychosis may have an autoimmune basis, but this has not translated through into clinical practice—there is no biochemical test able to accurately identify psychosis resulting ... -
Study of immunotherapy in antibody positive psychosis: feasibility and acceptability (SINAPPS1)
Lennox, Belinda; Tomei, Giuliano; Vincent, Sally-Anne; Yeeles, Ksenija; Pollard, Rebecca (2018-06-11)The main finding of the SINAPPS1 study is that immunotherapy can be delivered rapidly and safely to people with acute psychosis within an acute hospital setting. The treatments were tolerated and there were no cases of ...