Browsing by Author "External author(s) only"
Now showing items 1-20 of 222
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Advance care planning in patients referred to hospital for acute medical care
(2020-02)Advance care planning (ACP) is a voluntary process of discussion about future care between an individual and their care provider. ACP is a key focus of national policy as a means to improve patient centered care at the ... -
The Africa Ethics Working Group (AEWG): a model of collaboration for psychiatric genomic research in Africa [version 1; peer review: awaiting peer review]
(2021-07)The Africa Ethics Working Group (AEWG) is a South-South-North collaboration of bioethics and mental health researchers from sub-Saharan Africa, working to tackle emerging ethical challenges in global mental health research. ... -
Age-related response speed deficits arise from specific impairments in sensory evidence accumulation rate
(2021-11)Older adults exposed to enriched environments (EE) maintain relatively higher levels of cognitive function, even in the face of compromised markers of brain health. Response speed (RS) is often used as a simple proxy to ... -
Alcohol consumption is associated with reduced creatine levels in the hippocampus of older adults
(2019-11)Besides its well established susceptibility to ageing, the hippocampus has also been shown to be affected by alcohol consumption. Proton spectroscopy (1H-MRS) of the hippocampus, particularly at high-field 7T MRI, may ... -
Altered network stability in progressive supranuclear palsy
(2021-07)The clinical syndromes of Progressive Supranuclear Palsy (PSP) may be mediated by abnormal temporal dynamics of brain networks, due to the impact of atrophy, synapse loss and neurotransmitter deficits. We tested the ... -
Antimicrobial Peptides SLPI and Beta Defensin-1 in Sputum are Negatively Correlated with FEV1
(2021-05)Background: Chronic obstructive pulmonary disease (COPD) and asthma have heterogeneous inflammation with inhaled corticosteroids (ICS) as a mainstay of treatment. There is increased prevalence of non-typeable Haemophilus ... -
Are nursing associates the new kids on the block of the learning disability sector?
(2019-10)Health Education England’s £2 million learning disability recruitment drive will include 150 places for the recently created role of nursing associate. Last year Oxford Health NHS Foundation Trust began training ... -
Are People Ready for Personalized Brain Health? Perspectives of Research Participants in the Lifebrain Consortium
(2019-11)Background and Objectives A healthy brain is central to physical and mental well-being. In this multi-site, qualitative study, we investigated views and attitudes of adult participants in brain research studies on the ... -
Assessing Fluid Resuscitation in Adults with Sepsis Who Are Not Mechanically Ventilated: a Systematic Review of Diagnostic Test Accuracy Studies
(2019-05)BACKGROUND: Fluid resuscitation is a widely used intervention that is mandated in the management of sepsis. While its use can be life-saving, its overuse is associated with harm. Despite this, the best means of assessing ... -
Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study
(2020-03)Cardiovascular health in midlife is an established risk factor for cognitive function later in life. Knowing mechanisms of this associationmay allow preventative steps to be taken to preserve brain health and cognitive ... -
Associations Between Longitudinal Trajectories of Cognitive and Social Activities and Brain Health in Old Age
(2020-08)Importance Prior neuroimaging studies have found that late-life participation in cognitive (eg, reading) and social (eg, visiting friends and family) leisure activities are associated with magnetic resonance imaging (MRI) ... -
Associations between modifiable risk factors and white matter of the aging brain: insights from diffusion tensor imaging studies
(2019-08)There is increasing interest in factors that may modulate white matter (WM) breakdown and, consequentially, age-related cognitive and behavioral deficits. Recent diffusion tensor imaging studies have examined the relationship ... -
Associations between the household environment and stunted child growth in rural India: a cross-sectional analysis
(2019-03)Stunting is a major unresolved and growing health issue for India. Yet there remains scant evidence for the development and application of integrated, multifactorial child health interventions across India’s most rural ... -
The autoantibody-mediated encephalitides: from clinical observations to molecular pathogenesis
(2019-10)The autoimmune encephalitis (AE) syndromes have been characterised by the detection of autoantibodies in serum and/or cerebrospinal fluid which target the extracellular domains of specific neuroglial antigens. The clinical ... -
Barriers and facilitators of loaded self-managed exercises and physical activity in people with patellofemoral pain: understanding the feasibility of delivering a multicentred randomised controlled trial, a UK qualitative study
(2019-05)Objectives: There is an emergent body of evidence supporting exercise therapy and physical activity in the management of musculoskeletal pain. The purpose of this study was to explore potential barriers and facilitators ... -
Behavioural programmes for cigarette smoking cessation: investigating interactions between behavioural, motivational and delivery components in a systematic review and component network meta-analysis
(2022-01)To investigate the comparative and combined effectiveness of four types of components of behavioural interventions for cigarette smoking cessation: behavioural (e.g. counselling), motivational (e.g. focus on reasons to ... -
Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol
(2018-11)Introduction: Neurogenic claudication due to spinal stenosis is common in older adults. The effectiveness of conservative interventions is not known. The aim of the study is to estimate the clinical and cost-effectiveness ... -
Bilateral Permanent Childhood Hearing Loss and Health-Related Quality of Life in Adolescence
(2021-06)Little is known about the impact of bilateral permanent childhood hearing loss (PCHL) on health-related quality of life (HRQoL). The objective of this study was to describe preference-based and non-preference based HRQoL ... -
Blood pressure changes following antihypertensive medication reduction, by drug class and dose chosen for withdrawal: Exploratory analysis of data from the OPTiMISE trial
(2021-02)Aims: Deprescribing of antihypertensive drugs is recommended for some older patients with polypharmacy, but there is little evidence to inform which drug (or dose) should be withdrawn. This study used data from the ... -
Brain tumour segmentation using a triplanar ensemble of U-Nets on MR images
(2021-05)Gliomas appear with wide variation in their characteristics both in terms of their appearance and location on brain MR images, which makes robust tumour segmentation highly challenging, and leads to high inter-rater ...
