Browsing by Author "De Giorgi, Riccardo"
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Antidepressants plus benzodiazepines in major depressive disorder: a clinical dilemma with no recent answers from research
De Giorgi, Riccardo; De Cates, Angharad N (2020-10)Comorbid anxiety symptoms are common in depression, and adding benzodiazepines to antidepressant treatment may seem a rational clinical solution. Benzodiazepines also have potential to reduce the initial anxiety that may ... -
Ketamine for suicidal ideation: New trial challenges current thinking about ketamine
De Giorgi, Riccardo (2022-02)Will ketamine be given to eligible patients with suicidal ideation any time soon? This is hard to say, given the plausible concern that the widespread use of ketamine might trigger a new opioid style crisis.10 Whether ... -
Prevalence of Non-Affective Psychoses in Individuals with Autism Spectrum Disorders: A Systematic Review
De Crescenzo, Franco; De Giorgi, Riccardo (2019-08)Autism spectrum disorders (ASD) and non-affective psychoses such as schizophrenia are commonly acknowledged as discrete entities. Previous research has revealed evidence of high comorbidity between these conditions, but ... -
Psychosocial interventions in stimulant use disorders: a focus on women
De Giorgi, Riccardo; De Crescenzo, Franco (2017-07)Purpose of review: Stimulant use disorders are significant contributors to the global burden of disease, with a growing impact on women. Psychosocial interventions are the gold standard for treating this condition, but ... -
Psychosocial interventions in stimulant use disorders: a systematic review and qualitative synthesis of randomized controlled trials
De Giorgi, Riccardo; Economou, Alexis; De Crescenzo, Franco (2018-09)Stimulant use disorders are highly prevalent with a large burden of disease. Most clinical guidelines recommend psychosocial interventions, but there are no clear hierarchies or indications. Moreover, these interventions ... -
Rischio di mortalità con i farmaci antipsicotici nella popolazione psichiatrica anziana? Una revisione sistematica della letteratura
De Giorgi, Riccardo; Cipriani, Andrea (2016)Scopo dello studio: In Italia, gli anziani raggiungono quasi un quarto della popolazione generale. In questo sottogruppo, gli antipsicotici sono ampiamente prescritti: nonostante siano autorizzati esclusivamente per ... -
Statins for major depressive disorder: A systematic review and meta-analysis of randomized controlled trials
De Giorgi, Riccardo; De Crescenzo, Franco; Cowen, Philip J; Harmer, Catherine J (2021-03)The burden of depressive disorder is large and new treatment approaches are required. Repurposing widely available drugs such as statins may be a time- and cost-effective solution. Statins have anti-inflammatory and ... -
Statins in depression: a repurposed medical treatment can provide novel insights in mental health
De Giorgi, Riccardo; Cowen, Philip J; Harmer, Catherine J (2022-08)Depression has a large burden, but the development of new drugs for its treatment has proved difficult. Progresses in neuroscience have highlighted several physiopathological pathways, notably inflammatory and metabolic ... -
Strategies for preventing occupational stress in healthcare workers: past evidence, current problems
Dinkelaar, Bianca; De Giorgi, Riccardo (2021)The problem of occupational stress in healthcare workers is hardly new, but effective interventions in this area are lacking despite being sorely needed – especially in the ongoing Covid-19 pandemic. The review ... -
The tail wagging the dog: the diagnostic accuracy of first rank symptoms COMMENTARY ON… COCHRANE CORNER
Townsend, Leigh; De Giorgi, Riccardo (2019-10)Outcomes for people with schizophrenia are improved by expedient diagnosis and specific treatment. ICD-11 and DSM-5 have reduced the importance of Schneider's first rank symptoms (FRS) in the diagnosis of schizophrenia; ... -
Trainee Leadership Board: learning about NHS leadership
Stegen, Gerti; Leveson, Daniel; Llewelyn, Susan; De Giorgi, Riccardo (2018-03-27)Introduction: The development of a new generation of clinical leaders in the NHS has been increasingly endorsed by most recent literature in medical leadership and management. Despite providing academic rationale and ... -
Treatment of Inappropriate Sexual Behavior in Dementia
De Giorgi, Riccardo; Series, Hugh (2016-08)Inappropriate sexual behavior (ISB) is a relatively common and potentially disruptive form of behavior in people with dementia. It can cause considerable distress and put placements and people at risk. Yet it is poorly ... -
Vortioxetine for depression: the evidence for its current use in the UK: COMMENTARY ON… COCHRANE CORNER
De Giorgi, Riccardo (2018-12-17)The pharmacological treatment of depression is often hampered by side-effects and unsatisfactory response to treatment. Vortioxetine is one of the newest antidepressants on the market, purportedly with a different mechanism ... -
The wh-questions of network meta-analyses
De Giorgi, Riccardo (2019-10)Currently, network meta-analyses (NMAs) are the only technique that allow us to compare and rank numerous treatments across trials. Evidence produced by NMAs relies on pooled data from both direct and indirect comparisons ...