Browsing by Author "De Crescenzo, Franco"
Now showing items 1-10 of 10
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Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
De Crescenzo, Franco; Ostinelli, Edoardo; Kurtulmus, Ayse; Tomlinson, Anneka; Quested, Digby J; Cowen, Philip J; Efthimiou, Orestis; Cipriani, Andrea (2022-07)Background: Behavioural, cognitive, and pharmacological interventions can all be effective for insomnia. However, because of inadequate resources, medications are more frequently used worldwide. We aimed to estimate the ... -
Development and validation of a meta-learner for combining statistical and machine learning prediction models in individuals with depression
De Crescenzo, Franco; Ostinelli, Edoardo; Tomlinson, Anneka; Cipriani, Andrea (2022-05)The debate of whether machine learning models offer advantages over standard statistical methods when making predictions is ongoing. We discuss the use of a meta-learner model combining both approaches as an alternative. ... -
Melatonin In Acute Mania Investigation (MIAMI‐UK). A randomised controlled trial of add‐on melatonin in bipolar disorder
Quested, Digby J; Simpson, Jessica C; Cordey, Julia H; Economou, Alexis; De Crescenzo, Franco; Lawson, Jennifer; Al-Taiar, Hasanen; Lennox, Alison; Geddes, John R (2020-05)Objectives Current options for treating emergent episodes of hypomania and mania in bipolar disorder are limited. Our objective was to compare the effectiveness and safety of add‐on melatonin in hypomania or mania over ... -
Natural language processing for structuring clinical text data on depression using UK-CRIS
De Crescenzo, Franco; Harvey, Jade; Cipriani, Andrea (2020-02)Background Utilisation of routinely collected electronic health records from secondary care offers unprecedented possibilities for medical science research but can also present difficulties. One key issue is that medical ... -
Prevalence of Non-Affective Psychoses in Individuals with Autism Spectrum Disorders: A Systematic Review
De Crescenzo, Franco; De Giorgi, Riccardo (2019-08)Autism spectrum disorders (ASD) and non-affective psychoses such as schizophrenia are commonly acknowledged as discrete entities. Previous research has revealed evidence of high comorbidity between these conditions, but ... -
Psychosocial interventions in stimulant use disorders: a focus on women
De Giorgi, Riccardo; De Crescenzo, Franco (2017-07)Purpose of review: Stimulant use disorders are significant contributors to the global burden of disease, with a growing impact on women. Psychosocial interventions are the gold standard for treating this condition, but ... -
Psychosocial interventions in stimulant use disorders: a systematic review and qualitative synthesis of randomized controlled trials
De Giorgi, Riccardo; Economou, Alexis; De Crescenzo, Franco (2018-09)Stimulant use disorders are highly prevalent with a large burden of disease. Most clinical guidelines recommend psychosocial interventions, but there are no clear hierarchies or indications. Moreover, these interventions ... -
Real-world effect of antidepressants for depressive disorder in primary care: protocol of a population-based cohort study
De Crescenzo, Franco; Cipriani, Andrea (2020-06)Introduction Clinical guidelines recommend antidepressants as the first line of treatment for adults with moderate-to-severe depression. Randomised trials provide the best evidence on the comparative effectiveness of ... -
Statins for major depressive disorder: A systematic review and meta-analysis of randomized controlled trials
De Giorgi, Riccardo; De Crescenzo, Franco; Cowen, Philip J; Harmer, Catherine J (2021-03)The burden of depressive disorder is large and new treatment approaches are required. Repurposing widely available drugs such as statins may be a time- and cost-effective solution. Statins have anti-inflammatory and ... -
Sustain and reinforce transition from child to adult mental health care in Switzerland: study protocol
De Crescenzo, Franco (2020-11)A suboptimal transition in mental health care affects a young person’s wellbeing and health in the long run. We aim to identify a large cohort of young people approaching the transition boundary between child and adolescent ...