Browsing by Author "De Cates, Angharad N"
Now showing items 1-3 of 3
-
Antidepressants plus benzodiazepines in major depressive disorder: a clinical dilemma with no recent answers from research
De Giorgi, Riccardo; De Cates, Angharad N (2020-10)Comorbid anxiety symptoms are common in depression, and adding benzodiazepines to antidepressant treatment may seem a rational clinical solution. Benzodiazepines also have potential to reduce the initial anxiety that may ... -
Déjà-vu? Neural and behavioural effects of the 5-HT 4 receptor agonist, prucalopride, in a hippocampal-dependent memory task
De Cates, Angharad N; Wright, Lucy C; Gibson, Daisy; Cowen, Philip J; Harmer, Catherine J; Murphy, Susannah E (2021-10)Cognitive deficits commonly accompany psychiatric disorders but are often underrecognised, and difficult to treat. The 5-HT4 receptor is a promising potential treatment target for cognitive impairment because in animal ... -
Translating the promise of 5HT4 receptor agonists for the treatment of depression
Murphy, Susannah E; De Cates, Angharad N; Gillespie, Amy L; Godlewska, Beata R; Scaife, Jessica; Wright, Lucy C; Cowen, Philip J; Harmer, Catherine J (2020-02)Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are postsynaptic receptors that are located in ...