Browsing by Author "Harmer, Catherine J"
Now showing items 41-53 of 53
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Resting state functional connectivity patterns as biomarkers of treatment response to escitalopram in patients with major depressive disorder
Harmer, Catherine J; Godlewska, Beata R (2021-09)With no available response biomarkers, matching an appropriate antidepressant to an individual can be a lengthy process. Improving understanding of processes underlying treatment responsivity in depression is crucial for ... -
A single administration of ‘microbial’ D-alanine to healthy volunteers augments reaction to negative emotions: a comparison with D-serine
Capitao, Liliana; Harmer, Catherine J (2020-03)Background Activation of the glutamate N-methyl-D-Aspartate receptor (NMDAR) with its co-agonist D-serine has been shown to improve subjective mood in healthy volunteers. D-alanine is another potent NMDAR co-agonist which ... -
A single dose of fluoxetine reduces neural limbic responses to anger in depressed adolescents
Capitao, Liliana; Chapman, Robert; Murphy, Susannah E; James, Anthony; Cowen, Philip J; Harmer, Catherine J (2019-01-21)Depression in adolescence is frequently characterised by symptoms of irritability. Fluoxetine is the antidepressant with the most favourable benefit:risk ratio profile to treat adolescent depression, but the neural ... -
Statins for major depressive disorder: A systematic review and meta-analysis of randomized controlled trials
De Giorgi, Riccardo; De Crescenzo, Franco; Cowen, Philip J; Harmer, Catherine J (2021-03)The burden of depressive disorder is large and new treatment approaches are required. Repurposing widely available drugs such as statins may be a time- and cost-effective solution. Statins have anti-inflammatory and ... -
Statins in depression: a repurposed medical treatment can provide novel insights in mental health
De Giorgi, Riccardo; Cowen, Philip J; Harmer, Catherine J (2022-08)Depression has a large burden, but the development of new drugs for its treatment has proved difficult. Progresses in neuroscience have highlighted several physiopathological pathways, notably inflammatory and metabolic ... -
Subchronic treatment with St John’s wort produces a positive shift in emotional processing in healthy volunteers
Cowen, Philip J; Harmer, Catherine J (2018-11-28)The neurocognitive model of antidepressant treatment in depression states that antidepressants work by producing relatively immediate positive shifts in emotional processing, which translate into clinical improvement with ... -
Subclinical anxiety and depression are associated with deficits in attentional target facilitation, not distractor inhibition
Harmer, Catherine J (2019-06)Mood and anxiety disorders are associated with deficits in attentional control involving emotive and non-emotive stimuli. Current theories focus on impaired attentional inhibition of distracting stimuli in producing these ... -
Symptom Dynamics and Attention in Depression: Fatigue and Low Positive Affect are Associated With Reduced Orienting Efficiency
Harmer, Catherine J (2022-02)Depression is a heterogeneous mental disorder involving a complex interplay between potential etiological and maintenance factors. The current study examined how depression heterogeneity is related to attentional ... -
Translating the promise of 5HT4 receptor agonists for the treatment of depression
Murphy, Susannah E; De Cates, Angharad N; Gillespie, Amy L; Godlewska, Beata R; Scaife, Jessica; Wright, Lucy C; Cowen, Philip J; Harmer, Catherine J (2020-02)Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are postsynaptic receptors that are located in ... -
Ultradian hydrocortisone replacement alters neuronal processing, emotional ambiguity, affect and fatigue in adrenal insufficiency: The PULSES trial
Harmer, Catherine J (2023-10)Background: Primary adrenal insufficiency (PAI) mortality and morbidity remain unacceptably high, possibly arising as glucocorticoid replacement does not replicate natural physiology. A pulsatile subcutaneous pump can ... -
Use of Over-The-Counter Analgesics for Pain and Psychological Distress Among Adolescents: A Mixed Effects Approach in Cross-Sectional Survey Data From Norway
Harmer, Catherine J (2020-10)Background: Over-the-counter analgesics (OTCA) such as Paracetamol and Ibuprofen are frequently used by adolescents, and the route of administration and access at home allows unsupervised use. Psychological distress and ... -
Value of monitoring negative emotional bias in primary care in England for personalised antidepressant treatment: a modelling study
Harmer, Catherine J; Goodwin, Guy M (2019-11)Depressed patients often focus on negative life events. Effective antidepressant therapy reverses this negative emotional bias (NEB) within 1 week. Clinical therapeutic effect usually requires 4–6 weeks. The value of ... -
Variation in recognition of happy and sad facial expressions and self-reported depressive symptom severity: A prospective cohort study
Harmer, Catherine J (2019-06)Objective:Cognitive theories suggest people with depression interpret self-referential social information negatively. However, it is unclear whether these biases precede or follow depression. We investigated whether facial ...