Browsing by Author "Browning, Michael"
Now showing items 21-33 of 33
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Negative bias in interpretation and facial expression recognition in late life depression: A case control study.
Baruch, Nina; Behrman, Sophie; Wilkinson, Philip; Browning, Michael (2021-04)While cognitive bias in younger adults with depression has been extensively researched, there have been relatively few investigations of the presence of cognitive bias in late life depression (LLD). This exploratory study ... -
Neurocognitive processes in d-cycloserine augmented single-session exposure therapy for anxiety: A randomized placebo-controlled trial
Browning, Michael; Harmer, Catherine J (2020-06)Drugs targeting N-methyl-d-aspartate (NMDA) receptors and the ability to learn new associations have been proposed as adjunct treatments to boost the success of exposure therapy for anxiety disorders. However, the effects ... -
Pramipexole Enhances Reward Learning by Preserving Value Estimates
Halahakoon, Don Chamith; Geddes, John R; Cowen, Philip J; Harmer, Catherine J; Browning, Michael (2022-01)Background: Dopamine D2-like receptor agonists show promise as treatments for depression. They are thought to act by altering how individuals learn from rewarding experiences. However, the nature of these reward learning ... -
Pramipexole for the Treatment of Depression: Efficacy and Mechanisms
Browning, Michael; Halahakoon, Don Chamith (2023-11)Dopaminergic mechanisms are a plausible treatment target for patients with clinical depression but are relatively underexplored in conventional antidepressant medications. There is continuing interest in the potential ... -
Predicting treatment response in depression: the role of anterior cingulate cortex
Godlewska, Beata R; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2018)Background: Identification of biomarkers predicting therapeutic outcome to antidepressant treatment is one of the most important tasks in current research because it may transform the lengthy process of finding the right ... -
Predicting Treatment Response to Antidepressant Medication Using Early Changes in Emotional Processing.
Browning, Michael; Goodwin, Guy M; Harmer, Catherine J (2019-01)Antidepressants must be taken for weeks before response can be assessed with many patients not responding to the first medication prescribed. This often results in long delays before effective treatment is started. ... -
Pro-dopaminergic pharmacological interventions for anhedonia in depression: protocol for a living systematic review of human and non-human studies
Ostinelli, Edoardo; Browning, Michael; Cipriani, Andrea; Harmer, Catherine J (2023-10)Anhedonia is a key symptom of depression, and it has been suggested as a potential target for future individualised treatments. However, much is unknown about how interventions enhancing dopaminergic pathways may affect ... -
Reduction of aversive learning rates in Pavlovian conditioning by angiotensin II antagonist losartan
Browning, Michael; Reinecke, Andrea (2023-05)The angiotensin receptor blocker losartan has been linked to aspects of aversive learning such as fear acquisition and extinction, inhibition of aversive learning rates and reduced post-traumatic stress disorder (PTSD) ... -
Stimulating human prefrontal cortex increases reward learning
Browning, Michael (2021-01)Work in computational psychiatry suggests that mood disorders may stem from aberrant reinforcement learning processes. Specifically, it is proposed that depressed individuals believe that negative events are more informative ... -
Symptom trajectories in discontinuation trials.
Browning, Michael (2017-02)Many patients with clinical depression, particularly those with recurrent illness, are treated with maintenance antidepressants after an acute-phase response. But how effective is this approach? The effectiveness of ... -
Using Computational Psychiatry to Rule Out the Hidden Causes of Depression
Browning, Michael (2017-08)In an ideal world, our understanding of the causes of psychiatric disorders would progress by testing mechanistic hypotheses in experimental studies, using the results of these studies to identify situations in which the ... -
What is Computational Psychiatry Good For?
Browning, Michael (2022-09)It is rare in the field of biological psychiatry for hypotheses to be definitively refuted. Rather, topics of investigation drift into and out of fashion, often driven by the initial excitement of technological innovation, ... -
When Helping is Risky: Behavioral and Neurobiological Mechanisms of Prosocial Decisions Entailing Risk.
Cowen, Philip J; Browning, Michael (2020-03)Helping others can entail risks. Doctors that treat infectious patients may risk their own health, intervening in a fight can lead to injury, and organ donations can lead to medical complications. When helping others comes ...