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Title: | Elevated homocysteine and N-methyl-D-aspartate-receptor antibodies as a cause of behavioural and cognitive decline in 22q11.2 deletion syndrome |
Authors: | Banerjee, Subimal Lennox, Belinda |
Keywords: | Psychosis Biological Markers |
Issue Date: | Dec-2017 |
Citation: | Simon Vann Jones, Subimal Banerjee, A David Smith, Helga Refsum, Belinda Lennox; Elevated homocysteine and N-methyl-D-aspartate-receptor antibodies as a cause of behavioural and cognitive decline in 22q11.2 deletion syndrome, Oxford Medical Case Reports, Volume 2017, Issue 12, 1 December 2017, omx076 |
Abstract: | A 19-year-old male with 22q11.2 deletion syndrome presented with a 4-year history of cognitive decline and symptoms suggestive of atypical psychosis. Potential for elevated homocysteine and NMDA-receptor antibodies in the pathogenesis of his symptoms was investigated. He had elevated blood homocysteine level (18.7 μmol/l), low-normal vitamin B12 and folate levels and was positive for NMDA-receptor antibodies. Treatment with daily folinic acid (0.8 mg) and vitamin B12 (1 mg) led to dramatic improvement in his cognitive and behavioural presentation. Subsequent plasma exchange resulted in a further, significant clinical improvement. Homocysteine levels and NMDA-R antibodies should be investigated as potential causes of behavioural and cognitive symptoms in patients with 22q11.2 deletion syndrome. |
Description: | This is an Open Access article under the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/). Copyright The Authors 2017. |
URI: | https://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/81 |
Appears in Collections: | Schizophrenia and Psychotic Disorders |
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VJones_OMCR_2017.pdf | 114.4 kB | Adobe PDF | View/Open |
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