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https://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/196
Title: | Learning to optimize perceptual decisions through suppressive interactions in the human brain |
Authors: | Nettekoven, Caroline Hinson, Emily |
Keywords: | Neuroscience |
Issue Date: | Jan-2019 |
Citation: | Frangou, Polytimi; Emir, Uzay; Karlaftis, Vasilis; Nettekoven, Caroline; Hinson, Emily; Larcombe, Stephanie; Bridge, Holly; Stagg, Charlotte; Kourtzi, Zoe. Learning to optimize perceptual decisions through suppressive interactions in the human brain.Nature Communications(10)4742019 |
Abstract: | Translating noisy sensory signals to perceptual decisions is critical for successful interactions in complex environments. Learning is known to improve perceptual judgments by filtering external noise and task-irrelevant information. Yet, little is known about the brain mechanisms that mediate learning-dependent suppression. Here, we employ ultra-high field magnetic resonance spectroscopy of GABA to test whether suppressive processing in decision-related and visual areas facilitates perceptual judgments during training. We demonstrate that parietal GABA relates to suppression of task-irrelevant information, while learning-dependent changes in visual GABA relate to enhanced performance in target detection and feature discrimination tasks. Combining GABA measurements with functional brain connectivity demonstrates that training on a target detection task involves local connectivity and disinhibition of visual cortex, while training on a feature discrimination task involves inter-cortical interactions that relate to suppressive visual processing. Our findings provide evidence that learning optimizes perceptual decisions through suppressive interactions in decision-related networks. |
Description: | Published online at: https://doi.org/10.1038/s41467-019-08313-y This is an Open Access article under the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
URI: | https://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/196 |
Appears in Collections: | Clinical Decision Making |
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Nature.pdf | 1.21 MB | Adobe PDF | ![]() View/Open |
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