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https://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/1254
Title: | Paediatric traumatic brain injury as a risk factor for psychosis and psychotic symptoms: a systematic review and meta-analysis |
Authors: | Blackman, Graham |
Keywords: | Brain Injury Children and Adolescents Psychosis |
Issue Date: | Feb-2023 |
Citation: | Paediatric traumatic brain injury as a risk factor for psychosis and psychotic symptoms: a systematic review and meta-analysis King-Chi Yau, Grace Revill, Graham Blackman, Madiha Shaikh, Vaughan Bell medRxiv 2023.02.17.23286118; |
Abstract: | Psychosis is one of the most disabling psychiatric disorders. Paediatric traumatic brain injury (pTBI) has been cited as a developmental risk factor for psychosis, however this association has never been assessed meta-analytically. A systematic review and meta-analysis of the association between pTBI and subsequent psychotic disorders/symptoms was performed. The study was pre-registered (CRD42022360772) adopting a random-effects model to estimate meta-analytic odds ratio (OR) and 95% confidence interval (CI) using the Paule-Mandel estimator. Subgroup (study location, study design, psychotic disorder vs subthreshold symptoms, assessment type, and adult vs adolescent onset) and meta-regression (quality of evidence) analyses were also performed. The robustness of findings was assessed through sensitivity analyses. The meta-analysis is available online as a computational notebook with an open dataset. We identified 10 relevant studies and eight were included in the meta-analysis. Based on a pooled sample size of 479,686, the pooled OR for the association between pTBI and psychosis outcomes was 1.80 (95% CI [1.11, 2.95]). There were no subgroup effects and no outliers. Both psychotic disorder and subthreshold symptoms were associated with pTBI. The overall association remained robust after removal of low-quality studies, however the OR reduced to 1.43 (95% CI [1.04, 1.98]). A leave-one-out sensitivity analysis showed the association was robust to removal of all but one study which changed the estimate to marginally non-significant. We report cautious meta-analytic evidence for a positive association between pTBI and future psychosis. New evidence will be key in determining long-term reliability of this finding. |
Description: | Preprint |
URI: | https://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/1254 |
Appears in Collections: | Schizophrenia and Psychotic Disorders |
Files in This Item:
File | Description | Size | Format | |
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2023.02.17.23286118v4.full.pdf | Preprint | 268.94 kB | Adobe PDF | View/Open |
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