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Title: | Plasma glutathione suggests oxidative stress is equally present in early- and late- onset bipolar disorder |
Authors: | Singh, Nisha McMahon, Hannah Bilderbeck, Amy Reed, Zoe E Tunbridge, Elizabeth Brett, Daniel Geddes, John R Goodwin, Guy M |
Keywords: | Bipolar Disorder |
Issue Date: | Mar-2018 |
Citation: | Singh, Nisha; McMahon, Hannah; Bilderbeck, Amy; Reed, Zoe E; Tunbridge, Elizabeth; Brett, Daniel; Geddes, John R; Churchill, Grant C; Goodwin, Guy M. Plasma glutathione suggests oxidative stress is equally present in early- and late- onset bipolar disorder. Bipolar Disorders. 2018;1–7. |
Abstract: | We previously demonstrated oxidative stress in bipolar patients and a relationship between the age of illness onset and total glutathione, a principal antioxi- dant. In this study, we sought to replicate these findings in a new cohort of patients. Methods: We recruited bipolar patients from Warneford Hospital, Oxford, UK, of similar age and grouped them according to age of onset of illness. The early- onset group comprised patients with onset at <23 years, and the late group comprised pa- tients with onset at >30 years. A third group, comprising age- matched healthy volun- teers, was also included. Reduced and oxidized glutathione, cysteine, and cystine were determined in plasma, using high- performance liquid chromatography. Mitochondrial DNA copy number, measured in whole blood, was also compared be- tween patients and healthy controls. Results: Significant increases in oxidative stress were observed in the patient groups, compared with the control group; however, no differences in glutathione- related oxi- dative stress measures were detected between the early- and late- onset bipolar pa- tient groups. No differences were observed in the amount of mitochondrial DNA, and there was no correlation with mood state. Conclusion: Using a more accurate method to quantify oxidative stress than in our previous study, we show that oxidative stress is a consistent feature of bipolar disor- der. Although we did not reproduce our finding correlating age of onset of illness to oxidative stress, we have shown, once again, that oxidative stress is a consistent fea- ture of bipolar disorder |
URI: | https://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/105 |
ISSN: | 1399-5618 |
Appears in Collections: | Bipolar Disorder |
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