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The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function
(2019)
Genome-wide association studies (GWAS) of psychiatric phenotypes have tended to focus on categorical diagnoses, but to understand the biology of mental illness it may be more useful to study traits which cut across traditional ...
Unraveling Mechanisms of Patient-Specific NRXN1 Mutations in Neuropsychiatric Diseases Using Human Induced Pluripotent Stem Cells
(2020-03)
Rare heterozygous deletions in the neurexin 1 (NRXN1) gene robustly increase an individual's risk of developing neurological and psychiatric disorders. However, the molecular bases by which different mutations result in ...
7 Virtual reality (VR) for the treatment of mental health disorders
(2020-07)
Mental health disorders are very common, but far too few people receive the best treatments. Much greater access to the best psychological treatments may be achieved using automated delivery in virtual reality (VR). With ...
Overlap in genetic risk for cross-disorder vulnerability to mental disorders and genetic risk for altered subcortical brain volumes
(2021-01)
Background: There have been considerable recent advances in understanding the genetic architecture of psychiatric disorders as well as the underlying neurocircuitry. However, there is little work on the concordance of
genetic ...
Six-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19
(2021-01)
Background. Neurological and psychiatric sequelae of COVID-19 have been reported, but
there are limited data on incidence rates and relative risks.
Methods. Using retrospective cohort studies and time-to-event analysis, ...
Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA
(2020)
Background
Adverse mental health consequences of COVID-19, including anxiety and depression, have been widely predicted but not yet accurately measured. There are a range of physical health risk factors for COVID-19, but ...
The neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives
(2021-02)
There is accumulating evidence of the neurological and neuropsychiatric features of infection with SARS-CoV-2.
In this systematic review and meta-analysis, we aimed to describe the characteristics of the early literature ...
COVID and early intervention: the impact of COVID-19 on referrals to an early intervention service
(2021-06)
COVID-19 has a demonstratable impact on the population's mental health and is associated with an increased incidence of psychiatric disorders, including patients experiencing psychotic presentations. The aim of this study ...
What can siblings and cousins tell us about the role of early life family income in the aetiologies of violent crime, substance misuse and psychiatric morbidity?
(2022-03)
In our recent paper,1 we examined associations between family income during childhood and adolescence on subsequent risks of developing psychiatric disorders, having substance misuse problems and being arrested for a violent ...
Onset and recurrence of psychiatric disorders associated with anti-hypertensive drug classes
(2021-05)
The major anti-hypertensive (AHT) drug classes have been associated with differential risks of psychiatric disorders. However, existing data are limited largely to depression, and confounding variables have not always been ...