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Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression
(2018)
Risk-taking behaviour is an important component of several psychiatric disorders, including attention-deficit hyperactivity disorder, schizophrenia and bipolar disorder. Previously, two genetic loci have been associated ...
Dopaminergic modulation of regional cerebral blood flow: An arterial spin labelling study of genetic and pharmacological manipulation of COMT activity
(2021-07)
Dopamine has direct and complex vasoactive effects on cerebral circulation. Catechol-O-methyltransferase (COMT) regulates cortical dopamine, and its activity can be influenced both genetically and pharmacologically. COMT ...
Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes
(2021-04)
Alternative splicing (AS) is a key mechanism underlying cellular differentiation and a driver of
complexity in mammalian neuronal tissues. However, understanding of which isoforms are
differentially used or expressed and ...
Roadblock: improved annotations do not necessarily translate into new functional insights
(2021-11)
The advent of cost-effective high-throughput nucleotide sequencing means that information about the transcriptome is accruing at an exponential rate, rapidly refining our understanding of the diversity of gene products. ...
Which Dopamine Polymorphisms are Functional? Systematic Review and Meta-Analysis of COMT, DAT, DBH, DDC, DRD1-5, MAOA, MAOB, TH, VMAT1 and VMAT2
(2019-05)
BACKGROUND: Many polymorphisms in dopamine genes are reported to affect cognitive, imaging or
clinical phenotypes. It is often inferred or assumed that such associations are causal, mediated by a direct
effect of the ...