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Hierarchical modelling of functional brain networks in population and individuals from big fMRI data
(2021-02)
A major goal of large-scale brain imaging datasets is to provide resources for investigating heterogeneous
populations. Characterisation of functional brain networks for individual subjects from these datasets will have
an ...
Effect of glucose and sucrose on cognition in healthy humans: a systematic review and meta-analysis of interventional studies
(2021-02)
Evidence suggests that plasma glucose levels may influence cognitive performance, but this has not been systematically reviewed and quantified. Objective: The aim of this review was to investigate the potential effects of ...
Individual variation in brain microstructural-cognition relationships in aging
(2021-02)
While all individuals are susceptible to age-related cognitive decline, significant inter- and
intra-individual variability exists. However, the sources of this variation remain poorly understood. Here,
we examined the ...
Output planning at the input stage in visual working memory
(2021-03)
Working memory serves as the buffer between past sensations and future behavior, making it vital to understand not only how we encode and retain sensory information in memory but also how we plan for its upcoming use. We ...
Dopaminergic modulation of regional cerebral blood flow: An arterial spin labelling study of genetic and pharmacological manipulation of COMT activity
(2021-07)
Dopamine has direct and complex vasoactive effects on cerebral circulation. Catechol-O-methyltransferase (COMT) regulates cortical dopamine, and its activity can be influenced both genetically and pharmacologically. COMT ...
EMD: Empirical Mode Decomposition and Hilbert-Huang Spectral Analyses in Python
(2021-03)
The Empirical Mode Decomposition (EMD) package contains Python (>=3.5) functions for
analysis of non-linear and non-stationary oscillatory time series. EMD implements a family of
sifting algorithms, instantaneous frequency ...
Study Protocol: The Heart and Brain Study
(2021-03)
Background: It is well-established that what is good for the heart is good for the brain. Vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele ...
Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes
(2021-04)
Alternative splicing (AS) is a key mechanism underlying cellular differentiation and a driver of
complexity in mammalian neuronal tissues. However, understanding of which isoforms are
differentially used or expressed and ...
Introducing the tablet-based Oxford Cognitive Screen-Plus (OCS-Plus) as an assessment tool for subtle cognitive impairments
(2021-04)
Here, we present the Oxford Cognitive Screen-Plus, a computerised tablet-based screen designed to briefly assess domain-general cognition and provide more fine-grained measures of memory and executive function. The OCS-Plus ...
Looking ahead in working memory to guide sequential behaviour
(2021-06)
Working memory can maintain multiple sensory representations to serve unfolding sequential behaviour, such as while making tea or planning a route. How the human mind juggles internal representations as they become relevant ...