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Now showing items 1-10 of 21
Value of monitoring negative emotional bias in primary care in England for personalised antidepressant treatment: a modelling study
(2019-11)
Depressed patients often focus on negative life events. Effective antidepressant therapy reverses this negative emotional bias (NEB) within 1 week. Clinical therapeutic effect usually requires 4–6 weeks. The value of ...
Smoking and the risk for bipolar disorder: evidence from a bidirectional Mendelian randomisation study
(2019-09)
Background:There is increasing evidence that smoking is a risk factor for severe mental illness, including bipolar disorder. Conversely, patients with bipolar disorder might smoke more (often) as a result of the psychiatric ...
Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder
(2020-05)
Bipolar disorder is a chronic neuropsychiatric condition associated with mood instability, where patients present significant sleep and circadian rhythm abnormalities. Currently, the pathophysiology of bipolar disorder ...
Why sleep matters for young people who may get depressed
(2020-04)
Depression and anxiety are negative emotional states familiar to us all through personal experience. Less familiar are severe states of depression, in particular, which can actually shorten the lives of sufferers by over ...
Predicting Treatment Response to Antidepressant Medication Using Early Changes in Emotional Processing.
(2019-01)
Antidepressants must be taken for weeks before response can be assessed with many patients not responding to the first medication prescribed. This often results in long delays before effective treatment is started. ...
Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: A systematic review of evidence from observational studies
(2018-02)
Objectives: For the first time to present a systematic review of observational studies on the efficiency of lithium
monotherapy in comparison with other maintenance mood stabilizers in monotherapy and in combination.
Methods: ...
The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis
(2017-09-06)
Summary: Background Sleep difficulties might be a contributory causal factor in the occurrence of mental health problems. If
this is true, improving sleep should benefit psychological health. We aimed to determine whether ...
A signature-based machine learning model for distinguishing bipolar disorder and borderline personality disorder
(2018)
Mobile technologies offer new opportunities for prospective, high resolution monitoring of long-term health
conditions. The opportunities seem of particular promise in psychiatry where diagnoses often rely on retrospective
and ...
Experiences of remote mood and activity monitoring in bipolar disorder: a qualitative study
(2017-01)
Mobile technology enables high frequency mood monitoring and automated passive collection of date(e.g.actigraphy) from patients more efficiently and less intrusively than has previously been possible. Such techniques are ...
Comparative economic evaluation of quetiapine plus lamotrigine combination vs quetiapine monotherapy (and folic acid vs placebo) in patients with bipolar depression (cequel)
(2018-12)
Although not licensed for acute bipolar depression, lamotrigine has evidence for efficacy in trials and
its use is recommended in guidelines. So far there had been no prospective health economic evaluation of its
use. ...