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In Vivo Availability of Cannabinoid 1 Receptor Levels in Patients With First-Episode Psychosis
(2019-07)
Importance: Experimental and epidemiological studies implicate the cannabinoid 1 receptor (CB1R) in the pathophysiology of psychosis. However, whether CB1R levels are altered in the early stages of psychosis and whether ...
REBT and Psychosis
(2019-02)
Until comparatively recently, the idea of using REBT or any kind of cognitive psychotherapy for schizophrenia sounded like an oxymoron. The prevailing view in psychiatry and widely in the mental health field, was—and ...
Understanding, treating, and renaming grandiosedelusions: A qualitative study
(2019-11)
Background.Grandiose delusions are arguably the most neglected psychotic experience in research.
Objectives.We aimed to discover from patients: whether grandiose delusions have harmful consequences; the psychological ...
Automated virtual reality (VR) cognitive therapy for patients with psychosis: study protocol for a single-blind parallel group randomised controlled trial (gameChange).
(2019-08)
Introduction Many patients with psychosis experience everyday social situations as anxiety-provoking. The fears can arise, for example, from paranoia, hallucinations, social anxiety or negative-self beliefs. The fears lead ...
The comments of voices on the appearance of patients with psychosis: ‘the voices tell me that I am ugly’
(2019-09)
Background:There are high rates of obesity and low self-esteem in patients with psychosis. The occurrence of negative voice content directly about appearance is therefore plausible. Derogatory comments about appearance are ...
Cognitive Behavioural Therapy for Nightmares for Patients with Persecutory Delusions (Nites): An Assessor-Blind, Pilot Randomized Controlled Trial
(2019-05)
Objective:Nightmares are relatively common in patients experiencing psychosis but rarely assessed or treated. Nightmares may maintain persecutory delusions by portraying fears in sensory-rich detail. We tested the potential ...
Automated psychological therapy using virtual reality (VR) for patients with persecutory delusions: study protocol for a single-blind parallel-group randomised controlled trial (THRIVE)
(2019-01)
Persecutory delusions are a major psychiatric problem and are associated with a wide range of adverse outcomes. Our theoretical model views these delusions as unfounded threat beliefs which persist due to defence behaviours ...
Clozapine-induced pericarditis: an ethical dilemma
(2019-06)
Clozapine is an atypical antipsychotic used most frequently in the management of treatment-resistant schizophrenia, where severely unwell patients have failed to respond to standard antipsychotic therapy. Clozapine is ...
Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin
(2019-10)
There is increasing recognition in the neurological and psychiatric literature of patients with so-called isolated
psychotic presentations (ie, with no, or minimal, neurological features) who have tested positive for ...
The weeks before 100 persecutory delusions: the presence of many potential contributory causal factors
(2019-09)
Background:The period before the formation of a persecutory delusion may provide causal insights. Patient accounts are invaluable in informing this understanding.
Aims:To inform the understanding of delusion formation, ...