Browsing Schizophrenia and Psychotic Disorders by Author "Tunbridge, Elizabeth"
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CACNA1C (CaV1.2) and other L-type calcium channels in the pathophysiology and treatment of psychiatric disorders: Advances from functional genomics and pharmacoepidemiology
Harrison, Paul J; Colbourne, Lucy; Mould, Arne; Tunbridge, Elizabeth (2022-09)A role for voltage-gated calcium channels (VGCCs) in psychiatric disorders has long been postulated as part of a broader involvement of intracellular calcium signalling. However, the data were inconclusive and hard to ... -
Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia
Mould, Arne; Al-Juffali, Noura; Tunbridge, Elizabeth (2021-12)The cognitive dysfunction experienced by patients with schizophrenia represents a major unmet clinical need. We believe that enhancing synaptic function and plasticity by targeting kalirin may provide a novel means to ... -
New drug targets in psychiatry: Neurobiological considerations in the genomics era
Harrison, Paul J; Mould, Arne; Tunbridge, Elizabeth (2022-07)After a period of withdrawal, pharmaceutical companies have begun to reinvest in neuropsychiatric disorders, due to improvements in our understanding of these disorders, stimulated in part by genomic studies. However, ... -
Targeting synaptic plasticity in schizophrenia: insights from genomic studies
Hall, Nicola A; Tunbridge, Elizabeth (2021-08)Recent genomic findings identify many hundreds of genomic loci that are associated with schizophrenia. Consistent with data from the pregenomic era, genomic findings implicate synaptic function and plasticity as a tractable ...