Browsing Bipolar Disorder by Author "Geddes, John R"
Now showing items 1-13 of 13
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Adjunctive Psychotherapy for Bipolar Disorder A Systematic Review and Component Network Meta-analysis
Geddes, John R; Cipriani, Andrea (2020-10)Importance Several psychotherapy protocols have been evaluated as adjuncts to pharmacotherapy for patients with bipolar disorder, but little is known about their comparative effectiveness. Objective To use systematic ... -
Characterizing Affective Variability in Bipolar Disorder and Borderline Personality Disorder, and the Effects of Lithium, Using a Generative Model of Affect
Saunders, Kate E.A.; Harmer, Catherine J; Harrison, Paul J; Goodwin, Guy M; Geddes, John R; Browning, Michael (2022-02)The affective variability of Bipolar Disorder (BD) is thought to qualitatively differ from that of Borderline Personality Disorder (BPD), with changes in affect persisting for longer in BD. However, quantitative studies ... -
Comparative economic evaluation of quetiapine plus lamotrigine combination vs quetiapine monotherapy (and folic acid vs placebo) in patients with bipolar depression (cequel)
Geddes, John R; Gardiner, Alexandra; Rendell, Jennifer; Goodwin, Guy M; Simon, Judit (2018-12)Although not licensed for acute bipolar depression, lamotrigine has evidence for efficacy in trials and its use is recommended in guidelines. So far there had been no prospective health economic evaluation of its use. ... -
The costs of bipolar disorder in the United Kingdom
Simon, Judit; Goodwin, Guy M; Geddes, John R (2021-09)Objectives: To estimate the individual cost and population-level economic burden of Bipolar Disorder (BD), and explore the impact of clinical and sociodemographic factors on costs in the United Kingdom. Methods: Annual ... -
Effect of lithium on circadian rhythm in bipolar disorder: A systematic review and meta-analysis
Saunders, Kate E.A.; Cipriani, Andrea; Geddes, John R (2021-03)Circadian rhythm disruption is commonly reported in patients with bipolar disorder. Lithium has been suggested to have effects on the circadian clock, the biological basis of the circadian rhythm. The objective of the ... -
Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: A systematic review of evidence from observational studies
Geddes, John R; Goodwin, Guy M (2018-02)Objectives: For the first time to present a systematic review of observational studies on the efficiency of lithium monotherapy in comparison with other maintenance mood stabilizers in monotherapy and in combination. Methods: ... -
Experiences of remote mood and activity monitoring in bipolar disorder: a qualitative study
Saunders, Kate E.A.; Geddes, John R; Goodwin, Guy M (2017-01)Mobile technology enables high frequency mood monitoring and automated passive collection of date(e.g.actigraphy) from patients more efficiently and less intrusively than has previously been possible. Such techniques are ... -
Melatonin In Acute Mania Investigation (MIAMI‐UK). A randomised controlled trial of add‐on melatonin in bipolar disorder
Quested, Digby J; Simpson, Jessica C; Cordey, Julia H; Economou, Alexis; De Crescenzo, Franco; Lawson, Jennifer; Al-Taiar, Hasanen; Lennox, Alison; Geddes, John R (2020-05)Objectives Current options for treating emergent episodes of hypomania and mania in bipolar disorder are limited. Our objective was to compare the effectiveness and safety of add‐on melatonin in hypomania or mania over ... -
Mental health prior to and during the COVID-19 pandemic in individuals with bipolar disorder: Insights from prospective longitudinal data
Saunders, Kate E.A.; South, Matthew; Geddes, John R (2022-03)Many studies have examined the impact of COVID-19 on the mental health of the public, but few have focused on individuals with existing severe mental illness with longitudinal data before and during the pandemic. Aims: To ... -
Plasma glutathione suggests oxidative stress is equally present in early- and late- onset bipolar disorder
Singh, Nisha; McMahon, Hannah; Bilderbeck, Amy; Reed, Zoe E; Tunbridge, Elizabeth; Brett, Daniel; Geddes, John R; Goodwin, Guy M (2018-03)We previously demonstrated oxidative stress in bipolar patients and a relationship between the age of illness onset and total glutathione, a principal antioxi- dant. In this study, we sought to replicate these findings ... -
Psychosocial markers of age at onset in bipolar disorder: a machine learning approach
Joyce, Dan W; Geddes, John R; Saunders, Kate E.A. (2022-07)Bipolar disorder is a chronic and severe mental health disorder. Early stratification of individuals into subgroups based on age at onset (AAO) has the potential to inform diagnosis and early intervention. Yet, the ... -
A signature-based machine learning model for distinguishing bipolar disorder and borderline personality disorder
Goodwin, Guy M; Geddes, John R; Saunders, Kate E.A. (2018)Mobile technologies offer new opportunities for prospective, high resolution monitoring of long-term health conditions. The opportunities seem of particular promise in psychiatry where diagnoses often rely on retrospective and ... -
Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)
Geddes, John R (2021-07)Treatment Resistant Bipolar Depression (TRBD) is a major contributor to the burden of disease associated with Bipolar Disorder (BD). Treatment options for people experiencing bipolar depression are limited to three ...