Browsing Bipolar Disorder by Author "Cowen, Philip J"
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Changes in brain Glx in depressed bipolar patients treated with lamotrigine: A proton MRS study
Godlewska, Beata R; Masakai, Charles; Bargiotas, Theodoras; Cowen, Philip J (2019-03)Background Lamotrigine is a useful treatment in bipolar depression but requires several weeks of dose titration before its clinical effects can be assessed. Animal experimental studies suggest that lamotrigine lowers ... -
Lithium modulates striatal reward anticipation and prediction error coding in healthy volunteers
Volman, Inge; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2020-10)Lithium is one of the most effective mood-stabilizing medications in bipolar disorder. This study was designed to test whether lithium administration may stabilize mood via effects on reward processing. It was hypothesized ... -
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
Sharpley, Ann L; Williams, Clare; Holder, Adele A; Godlewska, Beata R; Macdonald, Orla; Cowen, Philip J (2020-09)Rationale Lithium is an effective prophylactic and anti-manic treatment in bipolar disorder; however, its use is declining through perceived poor tolerance and toxicity. Lithium inhibits inositol monophosphatase (IMPase), ...