Browsing Depressive Disorders by Author "Geddes, John R"
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Antidepressants might work for people with major depression: where do we go from here? (Comment)
Cipriani, Andrea; Geddes, John R (2018-06)The publication of our updated network meta-analysis about antidepressants for the acute treatment of major depression has generated a wide discussion in newspapers, social media, and scientific journals. Based on 522 ... -
Clinical- and cost-effectiveness of a technology-supported and solution-focused intervention (DIALOG+) in treatment of patients with chronic depression—study protocol for a multi-site, cluster randomised controlled trial [TACK]
Molodynski, Andrew; Geddes, John R (2022-03)Many with an acute depressive disorder go on to develop chronic depression, despite ongoing care. There are few specifically designed interventions to treat chronic depression. DIALOG+, a technology-assisted intervention ... -
Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis
Cipriani, Andrea; Geddes, John R (2018-04)BACKGROUND Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological treatments are available; however, because of ... -
Comparative efficacy and acceptability of antidepressants in the long-term treatment of major depression: protocol for a systematic review and networkmeta-analysis
Geddes, John R; Cipriani, Andrea (2019-05)Introduction: Pharmacotherapy plays an important role in the treatment of major depression. At the initiation of antidepressant treatment, both improvement of symptoms in the short term and relapse prevention in the long ... -
Network meta-analysis of antidepressants – Authors' reply
Cipriani, Andrea; Geddes, John R (2018-09-22)Comments on issues raised with Cipriani et al, 'Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis' ... -
Pramipexole Enhances Reward Learning by Preserving Value Estimates
Halahakoon, Don Chamith; Geddes, John R; Cowen, Philip J; Harmer, Catherine J; Browning, Michael (2022-01)Background: Dopamine D2-like receptor agonists show promise as treatments for depression. They are thought to act by altering how individuals learn from rewarding experiences. However, the nature of these reward learning ... -
A retrospective examination of care pathways in individuals with treatment-resistant depression
Harvey, Jade; Geddes, John R; Barrera, Alvaro (2021-05)Individuals with treatment-resistant depression (TRD) experience a high burden of illness. Current guidelines recommend a stepped care approach for treating depression, but the extent to which best-practice care pathways ... -
Sleep deprivation as a treatment for major depressive episodes: A systematic review and meta-analysis
Mitter, Pamina; Geddes, John R; Cipriani, Andrea (2022-05)Sleep deprivation, alone or in combination with pharmacological treatment and as part of a chronotherapy package, is of potential use for people with major depressive episodes, however the evidence base is still conflicting. ...