Browsing Depressive Disorders by Title
Now showing items 82-101 of 111
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Real-world effect of antidepressants for depressive disorder in primary care: protocol of a population-based cohort study
(2020-06)Introduction Clinical guidelines recommend antidepressants as the first line of treatment for adults with moderate-to-severe depression. Randomised trials provide the best evidence on the comparative effectiveness of ... -
Resting state functional connectivity patterns as biomarkers of treatment response to escitalopram in patients with major depressive disorder
(2021-09)With no available response biomarkers, matching an appropriate antidepressant to an individual can be a lengthy process. Improving understanding of processes underlying treatment responsivity in depression is crucial for ... -
A retrospective examination of care pathways in individuals with treatment-resistant depression
(2021-05)Individuals with treatment-resistant depression (TRD) experience a high burden of illness. Current guidelines recommend a stepped care approach for treating depression, but the extent to which best-practice care pathways ... -
Seeing sadness: Comorbid effects of loneliness and depression on emotional face processing
(2021-05)Background/objective: Loneliness and depression are highly comorbid, and both are associated with social processing deficits. However, there is a paucity of research aimed at differentiating emotional face-processing ... -
Selective publication of antidepressant trials and its influence on apparent efficacy: Updated comparisons and meta-analyses of newer versus older trials
(2022-01)Valid assessment of drug efficacy and safety requires an evidence base free of reporting bias. Using trial reports in Food and Drug Administration (FDA) drug approval packages as a gold standard, we previously found that ... -
Self-reported depression symptoms in haemodialysis patients: Bi-factor structures of two common measures and their association with clinical factors
(2018-08)Objective: To validate the factor structure of two common self-report depression tools in a large sample of haemodialysis (HD) patients and to examine their demographic and clinical correlates, including urine output, ... -
Side effect profile and comparative tolerability of 21 antidepressants in the acute treatment of major depression in adults: protocol for a network meta-analysis
(2019-05)Introduction: We have recently compared all second-generation as well as selected first-generation antidepressants in terms of efficacy and acceptability in the acute treatment of major depression. Here we present a protocol ... -
A single administration of ‘microbial’ D-alanine to healthy volunteers augments reaction to negative emotions: a comparison with D-serine
(2020-03)Background Activation of the glutamate N-methyl-D-Aspartate receptor (NMDAR) with its co-agonist D-serine has been shown to improve subjective mood in healthy volunteers. D-alanine is another potent NMDAR co-agonist which ... -
A single dose of fluoxetine reduces neural limbic responses to anger in depressed adolescents
(2019-01-21)Depression in adolescence is frequently characterised by symptoms of irritability. Fluoxetine is the antidepressant with the most favourable benefit:risk ratio profile to treat adolescent depression, but the neural ... -
Sleep deprivation as a treatment for major depressive episodes: A systematic review and meta-analysis
(2022-05)Sleep deprivation, alone or in combination with pharmacological treatment and as part of a chronotherapy package, is of potential use for people with major depressive episodes, however the evidence base is still conflicting. ... -
Statins for major depressive disorder: A systematic review and meta-analysis of randomized controlled trials
(2021-03)The burden of depressive disorder is large and new treatment approaches are required. Repurposing widely available drugs such as statins may be a time- and cost-effective solution. Statins have anti-inflammatory and ... -
Statins in depression: a repurposed medical treatment can provide novel insights in mental health
(2022-08)Depression has a large burden, but the development of new drugs for its treatment has proved difficult. Progresses in neuroscience have highlighted several physiopathological pathways, notably inflammatory and metabolic ... -
Stimulating human prefrontal cortex increases reward learning
(2021-01)Work in computational psychiatry suggests that mood disorders may stem from aberrant reinforcement learning processes. Specifically, it is proposed that depressed individuals believe that negative events are more informative ... -
Stress, inflammation and hippocampal subfields in depression: A 7 Tesla MRI Study
(2020-02)Experiencing stressful events throughout one’s life, particularly childhood trauma, increases the likelihood of being diagnosed with Major Depressive Disorder (MDD). Raised levels of cortisol, and markers of inflammation ... -
Subchronic treatment with St John’s wort produces a positive shift in emotional processing in healthy volunteers
(2018-11-28)The neurocognitive model of antidepressant treatment in depression states that antidepressants work by producing relatively immediate positive shifts in emotional processing, which translate into clinical improvement with ... -
Subclinical anxiety and depression are associated with deficits in attentional target facilitation, not distractor inhibition
(2019-06)Mood and anxiety disorders are associated with deficits in attentional control involving emotive and non-emotive stimuli. Current theories focus on impaired attentional inhibition of distracting stimuli in producing these ... -
Subjective cognitive complaints given in questionnaire: relationship with brain structure, cognitive performance and self-reported depressive symptoms in a 25-year retrospective cohort study
(2020-07)Subjective cognitive complaints are common but it is unclear whether they indicate an underlying pathological process or reflect affective symptoms. Method:800 community-dwelling older adults were drawn from the Whitehall ... -
Symptom Dynamics and Attention in Depression: Fatigue and Low Positive Affect are Associated With Reduced Orienting Efficiency
(2022-02)Depression is a heterogeneous mental disorder involving a complex interplay between potential etiological and maintenance factors. The current study examined how depression heterogeneity is related to attentional ... -
Symptom trajectories in discontinuation trials.
(2017-02)Many patients with clinical depression, particularly those with recurrent illness, are treated with maintenance antidepressants after an acute-phase response. But how effective is this approach? The effectiveness of ... -
Systematic Review and Meta-analysis: Depressive Symptoms and Risky Behaviors Among Adolescents in Low- and Middle-Income Countries
(2021-05)Several studies conducted in high-income countries have found an association between depressive symptoms and risky behaviors among adolescents. Evidence from low- and middle-income countries (LMICs), where 90% of the world’s ...