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Lithium modulates striatal reward anticipation and prediction error coding in healthy volunteers
(2020-10)Lithium is one of the most effective mood-stabilizing medications in bipolar disorder. This study was designed to test whether lithium administration may stabilize mood via effects on reward processing. It was hypothesized ... -
Living network meta-analysis compared with pairwise meta-analysis in comparative effectiveness research: empirical study
(2018-02-28)Objective:To examine whether the continuous updating of networks of prospectively planned randomised controlled trials (RCTs) (“living” network meta-analysis) provides strong evidence against the null hypothesis in comparative ... -
Living well while providing support: validation of LTCQ-Carer for assessing informal carers’ quality of life
(2023-08)Despite international policies to support the health and wellbeing of informal (family) caregivers, there is no consensus on how to evaluate the effectiveness of carer support. We aimed to develop and validate a new ... -
Living with persistent insomnia after cancer: Aqualitative analysis of impact and management
(2020-06)Objectives.To conduct a qualitative exploration of the lived experience of insomniadisorder and its management amongst a sample of mixed-diagnoses cancer survivors.Methods.Twenty-seven cancer survivors with persistent ... -
Long COVID rehabilitation: A collaborative approach to managing a new phenomenon
(2022-02)Purpose: Post COVID Syndrome (Long COVID) is the continuation of symptoms related to a COVID-like-illness after 12 weeks post onset (NICE Guidelines December 2020). Most recent ONS prevalence data (April 2021) predicts ... -
Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes
(2021-04)Alternative splicing (AS) is a key mechanism underlying cellular differentiation and a driver of complexity in mammalian neuronal tissues. However, understanding of which isoforms are differentially used or expressed and ... -
Longitudinal Changes in Parkinson’s Disease Symptoms with and Without Rapid Eye Movement Sleep Behavior Disorder: The Oxford Discovery Cohort Study
(2021-08)Background: Parkinson’s disease (PD) comorbid with rapid eye movement sleep behavior disorder (RBD) may show more severe motor and non motor symptoms, suggesting a distinct PD subtype. Objective: The aim of this study was ... -
Longitudinal cognitive performance in patients with Bipolar Disorder
(2020-01)Commentary: Neurocognitive impairments are a rather common occurrence in euthymic Bipolar Disorder (BD) patients. Understanding the degree of longitudinal stability of these deficits is vital in the management and treatment ... -
Longitudinal trajectory of cardiac magnetic resonance and cardiopulmonary exercise testing findings in moderate to severe COVID-19 and association with symptoms
(2021-10)Background Cardiac magnetic resonance (CMR) and cardiopulmonary exercise testing (CPET) have provided important insights into the prevalence of early cardiopulmonary abnormalities in COVID-19 patients. It is currently ... -
Long‐term benefits of digital cognitive behavioural therapy for insomnia: Follow‐up report from a randomized clinical trial
(2020-02)Digital cognitive behavioural therapy (dCBT) is an effective treatment for chronic insomnia and also improves well‐being and quality of life (QoL). We assessed whether these benefits are sustained and if the effects of ... -
Looking ahead in working memory to guide sequential behaviour
(2021-06)Working memory can maintain multiple sensory representations to serve unfolding sequential behaviour, such as while making tea or planning a route. How the human mind juggles internal representations as they become relevant ... -
Machine learning prediction will be part of future treatment of depression
(2023-02)Machine learning (ML) is changing the way that medicine is practiced. While already clinically utilised in diagnostic radiology and outcome prediction in intensive care unit, ML approaches in psychiatry remain nascent. ... -
A macroscopic link between interhemispheric tract myelination and cortico-cortical interactions during action reprogramming
(2021-12)Myelination has been increasingly implicated in the function and dysfunction of the adult human brain. Although it is known that axon myelination shapes axon physiology in animal models, it is unclear whether a similar ... -
Magnitude and variability of structural brain abnormalities in neuropsychiatric disease: protocol for a network meta-analysis of MRI studies
(2021-04)Introduction Structural MRI is the most frequently used method to investigate brain volume alterations in neuropsychiatric disease. Previous meta-analyses have typically focused on a single diagnosis, thereby precluding ... -
Making Mesothelioma Patient Research Happen: The United Kingdom Experience
(2020-06)In just a few years, the collaboration between an expert team of nurses, a charity committed to patients, the NHS, and successful health academics has resulted in an excellent, clinically relevant portfolio of research. ... -
Making sense of being recalled: a grounded theory
(2019-01)A high proportion of forensic mental health service users (FSUs) are recalled to secure hospitals from conditional discharge in the community. The limited research on recall to date has preliminarily identified why FSUs ... -
Making sense of child and adolescent mental health services (CAMHS): An audit of the referral journey and the use of routine outcome measures (ROMS)
(2021-03)There is increased emphasis on the national reporting of Routine Outcome Measures (ROMS) as a way of improving Child and Adolescent Mental Health Services (CAMHS). This data needs to be viewed in context so that reasons ... -
Making serious learning easy and fun at OHFT: Educational board games
(2020-04)Learning and knowledge sharing are of paramount importance at Oxford Health Foundation Trust which has recently embarked on a wide scale Apprenticeship program as well as other training courses. Oxford Health Library staff ... -
Management of patients with an advance decision and suicidal behaviour: a systematic review
(2019-03)Background The use of advance care planning and advance decisions for psychiatric care is growing. However, there is limited guidance on clinical management when a patient presents with suicidal behaviour and an advance ... -
Managing resources and reducing waste in healthcare settings
(2015-12)The NHS is under pressure to increase its effectiveness and productivity. Nurses are tasked with delivering effective and efficient care, as well as improving patient safety, experiences and results. The reduction of ...