dc.contributor.author | Murphy, Susannah E | |
dc.contributor.author | Wright, Lucy C | |
dc.contributor.author | Carson, James | |
dc.contributor.author | Van Assche, Indra | |
dc.contributor.author | O'Brien, Jessica | |
dc.contributor.author | Oyesanya, Mayowa | |
dc.contributor.author | Harmer, Catherine J | |
dc.date.accessioned | 2020-12-09T14:52:49Z | |
dc.date.available | 2020-12-09T14:52:49Z | |
dc.date.issued | 2020-10 | |
dc.identifier.citation | Catherine Hobbs, Susannah E. Murphy, Lucy Wright, James Carson, Indra Van Assche, Jessica O’Brien, Mayowa Oyesanya, Jie Sui, Marcus R. Munafò, David Kessler, Catherine J. Harmer and Katherine S. Button. Effect of acute citalopram on self-referential emotional processing and social cognition in healthy volunteers. BJPsych Open (2020) 6, e124, 1–9. | en |
dc.identifier.issn | 2056-4724 | |
dc.identifier.uri | https://oxfordhealth-nhs.archive.knowledgearc.net/handle/123456789/647 | |
dc.description | This is an Open
Access article, distributed under the terms of the Creative
Commons Attribution licence (http://creativecommons.org/
licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work
is properly cited | en |
dc.description.abstract | Background
Depression is characterised by negative views of the self.
Antidepressant treatment may remediate negative self-schema
through increasing processing of positive information about the
self. Changes in affective processing during social interactions
may increase expression of prosocial behaviours, improving
interpersonal communications.
Aims
To examine whether acute administration of citalopram is
associated with an increase in positive affective learning biases
about the self and prosocial behaviour.
Method
Healthy volunteers (n = 41) were randomised to either an acute
20 mg dose of citalopram or matched placebo in a betweensubjects double-blind design. Participants completed computerbased cognitive tasks designed to measure referential affective
processing, social cognition and expression of prosocial
behaviours.
Results
Participants administered citalopram made more cooperative
choices than those administered placebo in a prisoner’s
dilemma task (β = 20%, 95% CI: 2%, 37%). Exploratory analyses
indicated that participants administered citalopram showed
a positive bias when learning social evaluations about a friend
(β = 4.06, 95% CI: 0.88, 7.24), but not about the self or a stranger.
Similarly, exploratory analyses found evidence of increased
recall of positive words and reduced recall of negative words
about others (β = 2.41, 95% CI: 0.89, 3.93), but not the self, in the
citalopram group.
Conclusions
Participants administered citalopram showed greater prosocial
behaviours, increased positive recall and increased positive
learning of social evaluations towards others. The increase in
positive affective bias and prosocial behaviours towards others
may, at least partially, be a mechanism of antidepressant effect.
However, we found no evidence that citalopram influenced selfreferential processing. | en |
dc.description.sponsorship | Supported by the NIHR | en |
dc.description.uri | https://doi: 10.1192/bjo.2020.107 | en |
dc.language.iso | en | en |
dc.subject | Depressive Disorders | en |
dc.subject | Social Functioning | en |
dc.title | Effect of acute citalopram on self-referential emotional processing and social cognition in healthy volunteers | en |
dc.type | Article | en |