Conducting Research: Recent submissions
Now showing items 1-20 of 49
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Estimating and visualising the trade-off between benefits and harms on multiple clinical outcomes in network meta-analysis
(2023-11)The relative treatment effects estimated from network meta-analysis can be employed to rank treatments from the most preferable to the least preferable option. These treatment hierarchies are typically based on ranking ... -
Vitruvian plot: a visualisation tool for multiple outcomes in network meta-analysis
(2022-05)Objective A network meta-analysis (NMA) usually assesses multiple outcomes across several treatment comparisons. The Vitruvian plot aims to facilitate communication of multiple outcomes from NMAs to patients and ... -
Synthesizing cross-design evidence and cross-format data using network meta-regression
(2022-03)In network meta-analysis (NMA), we synthesize all relevant evidence about health outcomes with competing treatments. The evidence may come from randomized controlled trials (RCT) or non-randomized studies (NRS) as individual ... -
A Systematic Review of the Reporting Quality of Observational Studies That Use Mediation Analyses
(2022-02)Mediation analysis is a common statistical method used to investigate mechanisms of health exposure and interventions. The reporting quality of mediation studies used in randomised controlled trials has been considered ... -
Promoting inclusivity by ensuring that all patients with mental health issues are offered research opportunities in the NHS
(2022-01)Research-active clinical services have lower mortality rates and produce higher quality care outcomes, however, recruiting participants to clinical research in the National Health System (NHS) remains challenging.1 A recent ... -
Burden of cancer trial participation: A qualitative sub-study of the INTERIM feasibility RCT
(2021-11)A qualitative sub-study was carried out within a larger phase II feasibility trial, to identify and describe the burden experienced by advanced melanoma patients participating in a clinical trial and the factors affecting ... -
Co-producing Human and Animal Experimental Subjects: Exploring the Views of UK COVID-19 Vaccine Trial Participants on Animal Testing
(2021-11)Preclinical (animal) testing and human testing of drugs and vaccines are rarely considered by social scientists side by side. Where this is done, it is typically for theoretically exploring the ethics of the two situations ... -
ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis
(2021-11)Selective outcome reporting and publication bias threaten the validity of systematic reviews and meta-analyses and can affect clinical decision-making. A rigorous method to evaluate the impact of this bias on the results ... -
How to build a game for empirical bioethics research: The case of ‘Tracing Tomorrow’
(2021-10)It is becoming increasingly clear that the field of empirical bioethics requires methodological innovations that can keep up with the scale and pace of contemporary research in health and medicine. With that in mind, we ... -
The Africa Ethics Working Group (AEWG): a model of collaboration for psychiatric genomic research in Africa [version 1; peer review: awaiting peer review]
(2021-07)The Africa Ethics Working Group (AEWG) is a South-South-North collaboration of bioethics and mental health researchers from sub-Saharan Africa, working to tackle emerging ethical challenges in global mental health research. ... -
The wh-questions of network meta-analyses
(2019-10)Currently, network meta-analyses (NMAs) are the only technique that allow us to compare and rank numerous treatments across trials. Evidence produced by NMAs relies on pooled data from both direct and indirect comparisons ... -
Dealing with categorical risk data when extracting data for meta-analysis
(2021-01)A common problem in meta-analysis of observational studies arises when the exposure variable is categorical rather than continuous. These data may be referred to as quantile or quintile data (depending on the number of ... -
Extracting data from diagnostic test accuracy studies for meta-analysis
(2021-01)It is important that DTA reviews summarise all the available evidence. Studies in which the necessary information is not fully reported should not necessarily be excluded from pooled analyses. As reported in this article, ... -
Ethical Issues in Consent for the Re-use of Data in Health Data Platforms
(2020-12)Data platforms represent a new paradigm for carrying out health research. In the platform model, datasets are pooled for remote access and analysis, so novel insights for developing better stratified and / or personalised ... -
Informing National Health Service patients about participation in clinical research: A comparison of opt-in and opt-out approaches across the United Kingdom
(2020-11)Objective: Recruitment to clinical research in the National Health Service remains challenging. One barrier is accessing patients to discuss research participation. Two general approaches are used in the United Kingdom ... -
Producing and using timely comparative evidence on drugs: lessons from clinical trials for covid-19
(2020-10)Since the early days of the novel coronavirus outbreak, a record number of studies have been launched to test several repurposed and new medicines as potential treatments for covid-19 An analysis by the news organisation ... -
Pharmaceutical industry, academia and people with experience of mental illness as partners in research: a need for ethical guidance [version 1; peer review: 1 not approved]
(2020-08)Background: Several social and policy developments have led to research partnerships in mental health research, which depart from traditional research models. One form of such partnerships is among research institutions, ... -
Ethical challenges in Research, Industry and People Partnerships in mental health
(2020-08)Advancements in mental health research, social changes and policy developments have led to the emergence of new forms of research partnerships, which bring together research institutions, public companies and lay people ... -
Gamifying Bioethics: A Case Study of Co-Designing Empirical Tools with Adolescents
(2020-07)Research in bioethics largely relies on interviews and surveys, which engage participants with scenarios that are distal in time and place to an actual situation. However, context and embodiment are relevant to moral ... -
Using local communities to establish geographical boundaries for case studies
(2019-02)Background Case studies are widely used in the social sciences to explore complex phenomena in natural settings. Applying boundaries is vital to ensure cases are easily identifiable and similar enough to be treated as ...
