Browsing Conducting Research by Author "Cipriani, Andrea"
Now showing items 1-15 of 15
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Barriers and incentives to recruitment in mental health clinical trials
Cipriani, Andrea (2019-05)Research provides valuable information that improves patients’ outcomes and should inform clinical decision-making.1 There are many research methodologies2 and randomised controlled trials (RCTs) are at the top of the ... -
Combining Pharmacological and Nonpharmacological Interventions in Network Meta-analysis in Psychiatry
Cipriani, Andrea (2019-04)Network meta-analyses (NMAs) assess the comparative associations of 2 or more interventions even if they have not been compared in a randomized clinical trial.1 The validity of NMAs is founded on the assumption of transitivity ... -
Consent to discuss participation in research: a pilot study
Potts, Jennifer; Barrera, Alvaro; Hancock, Mark; Bell, Stuart; Cipriani, Andrea; Geddes, John R; Henshall, Catherine (2019-09)Background. Equitable access to research studies needs to be increased for all patients. There is debate about which is the best approach to use to discuss participation in research in real-world clinical settings. Objective. ... -
Estimating and visualising the trade-off between benefits and harms on multiple clinical outcomes in network meta-analysis
Cipriani, Andrea (2023-11)The relative treatment effects estimated from network meta-analysis can be employed to rank treatments from the most preferable to the least preferable option. These treatment hierarchies are typically based on ranking ... -
Ethical implications of poor comparative effectiveness evidence: obligations in industry-research partnerships
Cipriani, Andrea (2020-03)Which treatment is best for me? This question is at the centre of the clinical consultation. And yet, too often, the question is not answerable with available evidence on drugs and devices. The two Lancet Series papers on ... -
Impact of placebo arms on outcomes in antidepressant trials: systematic review and meta-regression analysis
Cipriani, Andrea (2018-06)There is debate in the literature as to whether inclusion of a placebo arm may alter characteristics of antidepressant trials. However, previous research has focused on response rates of various antidepressants on average ... -
Informing National Health Service patients about participation in clinical research: A comparison of opt-in and opt-out approaches across the United Kingdom
Cipriani, Andrea; Henshall, Catherine; Potts, Jennifer; Hancock, Mark; Underwood, Mark; Broughton, Nick; Ede, Roger; Kernot, Catherine; O'Neill, Lorcan; Geddes, John R (2020-11)Objective: Recruitment to clinical research in the National Health Service remains challenging. One barrier is accessing patients to discuss research participation. Two general approaches are used in the United Kingdom ... -
The Kilim plot: A tool for visualizing network meta‐analysis results for multiple outcomes
Cipriani, Andrea; Tomlinson, Anneka (2020-06)Network meta‐analysis (NMA) can be used to compare multiple competing treatments for the same disease. In practice, usually a range of outcomes is of interest. As the number of outcomes increases, summarizing results from ... -
Living network meta-analysis compared with pairwise meta-analysis in comparative effectiveness research: empirical study
Cipriani, Andrea (2018-02-28)Objective:To examine whether the continuous updating of networks of prospectively planned randomised controlled trials (RCTs) (“living” network meta-analysis) provides strong evidence against the null hypothesis in comparative ... -
Network meta-analysis of antidepressants – Authors' reply
Cipriani, Andrea; Geddes, John R (2018-09-22)Comments on issues raised with Cipriani et al, 'Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis' ... -
Producing and using timely comparative evidence on drugs: lessons from clinical trials for covid-19
Cipriani, Andrea (2020-10)Since the early days of the novel coronavirus outbreak, a record number of studies have been launched to test several repurposed and new medicines as potential treatments for covid-19 An analysis by the news organisation ... -
Promoting inclusivity by ensuring that all patients with mental health issues are offered research opportunities in the NHS
Henshall, Catherine; Jones, Helen; Smith, Tanya; Cipriani, Andrea (2022-01)Research-active clinical services have lower mortality rates and produce higher quality care outcomes, however, recruiting participants to clinical research in the National Health System (NHS) remains challenging.1 A recent ... -
ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis
Cipriani, Andrea (2021-11)Selective outcome reporting and publication bias threaten the validity of systematic reviews and meta-analyses and can affect clinical decision-making. A rigorous method to evaluate the impact of this bias on the results ... -
Synthesizing cross-design evidence and cross-format data using network meta-regression
Cipriani, Andrea (2022-03)In network meta-analysis (NMA), we synthesize all relevant evidence about health outcomes with competing treatments. The evidence may come from randomized controlled trials (RCT) or non-randomized studies (NRS) as individual ... -
Vitruvian plot: a visualisation tool for multiple outcomes in network meta-analysis
Ostinelli, Edoardo; Zangani, Caroline; Smith, Katharine A; Cipriani, Andrea (2022-05)Objective A network meta-analysis (NMA) usually assesses multiple outcomes across several treatment comparisons. The Vitruvian plot aims to facilitate communication of multiple outcomes from NMAs to patients and ...