Browsing Conducting Research by Title
Now showing items 9-28 of 49
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Collecting self-report research data with people with dementia within care home clinical trials: Benefits, challenges and best practice
(2019-08)One-third of people with dementia live in care home settings and in order to deliver better evidence-based care, robust research including clinical trials is required. Concerns have been raised by researchers about the ... -
Combining Pharmacological and Nonpharmacological Interventions in Network Meta-analysis in Psychiatry
(2019-04)Network meta-analyses (NMAs) assess the comparative associations of 2 or more interventions even if they have not been compared in a randomized clinical trial.1 The validity of NMAs is founded on the assumption of transitivity ... -
Consent to discuss participation in research: a pilot study
(2019-09)Background. Equitable access to research studies needs to be increased for all patients. There is debate about which is the best approach to use to discuss participation in research in real-world clinical settings. Objective. ... -
Co‐producing research with youth: The NeurOx young people’s advisory group model
(2019-03)Context: The 1989 UN Convention on the Rights of the Child states that children have the right to be heard in all matters affecting them. The Convention inspired a surge in research that investigates young people's ... -
Dealing with categorical risk data when extracting data for meta-analysis
(2021-01)A common problem in meta-analysis of observational studies arises when the exposure variable is categorical rather than continuous. These data may be referred to as quantile or quintile data (depending on the number of ... -
Development of A Guideline for Reporting Mediation Analyses (AGReMA)
(2020-02)There are a growing number of studies using mediation analysis to understand the mechanisms of health interventions and exposures. Recent work has shown that the reporting of these studies is heterogenous and incomplete. ... -
Difficult conversations? Engaging patients in reducing waste in health care
(2016)Purpose – Reducing waste in health care can result in savings that could be used to meet the projected shortfall in NHS funding or to meet the care needs of vulnerable groups. Patients and their families can contribute ... -
Estimating and visualising the trade-off between benefits and harms on multiple clinical outcomes in network meta-analysis
(2023-11)The relative treatment effects estimated from network meta-analysis can be employed to rank treatments from the most preferable to the least preferable option. These treatment hierarchies are typically based on ranking ... -
Ethical challenges in Research, Industry and People Partnerships in mental health
(2020-08)Advancements in mental health research, social changes and policy developments have led to the emergence of new forms of research partnerships, which bring together research institutions, public companies and lay people ... -
Ethical implications of poor comparative effectiveness evidence: obligations in industry-research partnerships
(2020-03)Which treatment is best for me? This question is at the centre of the clinical consultation. And yet, too often, the question is not answerable with available evidence on drugs and devices. The two Lancet Series papers on ... -
Ethical Issues in Consent for the Re-use of Data in Health Data Platforms
(2020-12)Data platforms represent a new paradigm for carrying out health research. In the platform model, datasets are pooled for remote access and analysis, so novel insights for developing better stratified and / or personalised ... -
Extracting data from diagnostic test accuracy studies for meta-analysis
(2021-01)It is important that DTA reviews summarise all the available evidence. Studies in which the necessary information is not fully reported should not necessarily be excluded from pooled analyses. As reported in this article, ... -
Gamifying Bioethics: A Case Study of Co-Designing Empirical Tools with Adolescents
(2020-07)Research in bioethics largely relies on interviews and surveys, which engage participants with scenarios that are distal in time and place to an actual situation. However, context and embodiment are relevant to moral ... -
How to build a game for empirical bioethics research: The case of ‘Tracing Tomorrow’
(2021-10)It is becoming increasingly clear that the field of empirical bioethics requires methodological innovations that can keep up with the scale and pace of contemporary research in health and medicine. With that in mind, we ... -
Impact of placebo arms on outcomes in antidepressant trials: systematic review and meta-regression analysis
(2018-06)There is debate in the literature as to whether inclusion of a placebo arm may alter characteristics of antidepressant trials. However, previous research has focused on response rates of various antidepressants on average ... -
Informing National Health Service patients about participation in clinical research: A comparison of opt-in and opt-out approaches across the United Kingdom
(2020-11)Objective: Recruitment to clinical research in the National Health Service remains challenging. One barrier is accessing patients to discuss research participation. Two general approaches are used in the United Kingdom ... -
Investigating assumptions of vulnerability: A case study of the exclusion of psychiatric inpatients as participants in genetic research in low‐ and middle‐income contexts
(2020-01)Psychiatric genetic research investigates the genetic basis of psychiatric disorders with the aim of more effectively understanding, treating, or, ultimately, preventing such disorders. Given the challenges of recruiting ... -
Investigating causal mechanisms in randomised controlled trials
(2019-08)Introduction: In some randomised trials, the primary interest is in the mechanisms by which an intervention exerts its effects on health outcomes. That is, clinicians and policy-makers may be interested in how the intervention ... -
The Kilim plot: A tool for visualizing network meta‐analysis results for multiple outcomes
(2020-06)Network meta‐analysis (NMA) can be used to compare multiple competing treatments for the same disease. In practice, usually a range of outcomes is of interest. As the number of outcomes increases, summarizing results from ... -
Living network meta-analysis compared with pairwise meta-analysis in comparative effectiveness research: empirical study
(2018-02-28)Objective:To examine whether the continuous updating of networks of prospectively planned randomised controlled trials (RCTs) (“living” network meta-analysis) provides strong evidence against the null hypothesis in comparative ...