Browsing Conducting Research by Issue Date
Now showing items 41-49 of 49
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How to build a game for empirical bioethics research: The case of ‘Tracing Tomorrow’
(2021-10)It is becoming increasingly clear that the field of empirical bioethics requires methodological innovations that can keep up with the scale and pace of contemporary research in health and medicine. With that in mind, we ... -
Co-producing Human and Animal Experimental Subjects: Exploring the Views of UK COVID-19 Vaccine Trial Participants on Animal Testing
(2021-11)Preclinical (animal) testing and human testing of drugs and vaccines are rarely considered by social scientists side by side. Where this is done, it is typically for theoretically exploring the ethics of the two situations ... -
ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis
(2021-11)Selective outcome reporting and publication bias threaten the validity of systematic reviews and meta-analyses and can affect clinical decision-making. A rigorous method to evaluate the impact of this bias on the results ... -
Burden of cancer trial participation: A qualitative sub-study of the INTERIM feasibility RCT
(2021-11)A qualitative sub-study was carried out within a larger phase II feasibility trial, to identify and describe the burden experienced by advanced melanoma patients participating in a clinical trial and the factors affecting ... -
Promoting inclusivity by ensuring that all patients with mental health issues are offered research opportunities in the NHS
(2022-01)Research-active clinical services have lower mortality rates and produce higher quality care outcomes, however, recruiting participants to clinical research in the National Health System (NHS) remains challenging.1 A recent ... -
A Systematic Review of the Reporting Quality of Observational Studies That Use Mediation Analyses
(2022-02)Mediation analysis is a common statistical method used to investigate mechanisms of health exposure and interventions. The reporting quality of mediation studies used in randomised controlled trials has been considered ... -
Synthesizing cross-design evidence and cross-format data using network meta-regression
(2022-03)In network meta-analysis (NMA), we synthesize all relevant evidence about health outcomes with competing treatments. The evidence may come from randomized controlled trials (RCT) or non-randomized studies (NRS) as individual ... -
Vitruvian plot: a visualisation tool for multiple outcomes in network meta-analysis
(2022-05)Objective A network meta-analysis (NMA) usually assesses multiple outcomes across several treatment comparisons. The Vitruvian plot aims to facilitate communication of multiple outcomes from NMAs to patients and ... -
Estimating and visualising the trade-off between benefits and harms on multiple clinical outcomes in network meta-analysis
(2023-11)The relative treatment effects estimated from network meta-analysis can be employed to rank treatments from the most preferable to the least preferable option. These treatment hierarchies are typically based on ranking ...