Browsing Conducting Research by Issue Date
Now showing items 21-40 of 49
-
Collecting self-report research data with people with dementia within care home clinical trials: Benefits, challenges and best practice
(2019-08)One-third of people with dementia live in care home settings and in order to deliver better evidence-based care, robust research including clinical trials is required. Concerns have been raised by researchers about the ... -
Investigating causal mechanisms in randomised controlled trials
(2019-08)Introduction: In some randomised trials, the primary interest is in the mechanisms by which an intervention exerts its effects on health outcomes. That is, clinicians and policy-makers may be interested in how the intervention ... -
Consent to discuss participation in research: a pilot study
(2019-09)Background. Equitable access to research studies needs to be increased for all patients. There is debate about which is the best approach to use to discuss participation in research in real-world clinical settings. Objective. ... -
The wh-questions of network meta-analyses
(2019-10)Currently, network meta-analyses (NMAs) are the only technique that allow us to compare and rank numerous treatments across trials. Evidence produced by NMAs relies on pooled data from both direct and indirect comparisons ... -
Measuring the impact of participatory research in psychiatry: How the search for epistemic justifications obscures ethical considerations
(2019-12)Both within politics and practice, the field of psychiatry is undergoing a significant transformation, as increasing emphasis is placed on the importance of involving those with lived experience in research. In response ... -
A year in statistics—the view from the trenches
(2020-01)Editorial: Last year we launched the EBM Methods Verdicts as part of an attempt to keep on top of developments in statistics that will impact on the way we do research.1 2 We focused on statistical methods and in particular ... -
Investigating assumptions of vulnerability: A case study of the exclusion of psychiatric inpatients as participants in genetic research in low‐ and middle‐income contexts
(2020-01)Psychiatric genetic research investigates the genetic basis of psychiatric disorders with the aim of more effectively understanding, treating, or, ultimately, preventing such disorders. Given the challenges of recruiting ... -
When Deploying Predictive Algorithms, Are Summary Performance Measures Sufficient?
(2020-01)The last decade’s growth in artificial intelligence, machine learning, and statistical methods for high-dimensional data has driven a zeitgeist of prediction (or forecasting) in medicine and psychiatry. Algorithms for ... -
Development of A Guideline for Reporting Mediation Analyses (AGReMA)
(2020-02)There are a growing number of studies using mediation analysis to understand the mechanisms of health interventions and exposures. Recent work has shown that the reporting of these studies is heterogenous and incomplete. ... -
Ethical implications of poor comparative effectiveness evidence: obligations in industry-research partnerships
(2020-03)Which treatment is best for me? This question is at the centre of the clinical consultation. And yet, too often, the question is not answerable with available evidence on drugs and devices. The two Lancet Series papers on ... -
The Kilim plot: A tool for visualizing network meta‐analysis results for multiple outcomes
(2020-06)Network meta‐analysis (NMA) can be used to compare multiple competing treatments for the same disease. In practice, usually a range of outcomes is of interest. As the number of outcomes increases, summarizing results from ... -
Gamifying Bioethics: A Case Study of Co-Designing Empirical Tools with Adolescents
(2020-07)Research in bioethics largely relies on interviews and surveys, which engage participants with scenarios that are distal in time and place to an actual situation. However, context and embodiment are relevant to moral ... -
Ethical challenges in Research, Industry and People Partnerships in mental health
(2020-08)Advancements in mental health research, social changes and policy developments have led to the emergence of new forms of research partnerships, which bring together research institutions, public companies and lay people ... -
Pharmaceutical industry, academia and people with experience of mental illness as partners in research: a need for ethical guidance [version 1; peer review: 1 not approved]
(2020-08)Background: Several social and policy developments have led to research partnerships in mental health research, which depart from traditional research models. One form of such partnerships is among research institutions, ... -
Producing and using timely comparative evidence on drugs: lessons from clinical trials for covid-19
(2020-10)Since the early days of the novel coronavirus outbreak, a record number of studies have been launched to test several repurposed and new medicines as potential treatments for covid-19 An analysis by the news organisation ... -
Informing National Health Service patients about participation in clinical research: A comparison of opt-in and opt-out approaches across the United Kingdom
(2020-11)Objective: Recruitment to clinical research in the National Health Service remains challenging. One barrier is accessing patients to discuss research participation. Two general approaches are used in the United Kingdom ... -
Ethical Issues in Consent for the Re-use of Data in Health Data Platforms
(2020-12)Data platforms represent a new paradigm for carrying out health research. In the platform model, datasets are pooled for remote access and analysis, so novel insights for developing better stratified and / or personalised ... -
Extracting data from diagnostic test accuracy studies for meta-analysis
(2021-01)It is important that DTA reviews summarise all the available evidence. Studies in which the necessary information is not fully reported should not necessarily be excluded from pooled analyses. As reported in this article, ... -
Dealing with categorical risk data when extracting data for meta-analysis
(2021-01)A common problem in meta-analysis of observational studies arises when the exposure variable is categorical rather than continuous. These data may be referred to as quantile or quintile data (depending on the number of ... -
The Africa Ethics Working Group (AEWG): a model of collaboration for psychiatric genomic research in Africa [version 1; peer review: awaiting peer review]
(2021-07)The Africa Ethics Working Group (AEWG) is a South-South-North collaboration of bioethics and mental health researchers from sub-Saharan Africa, working to tackle emerging ethical challenges in global mental health research. ...