Browsing Conducting Research by Title
Now showing items 18-37 of 49
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Ethical implications of poor comparative effectiveness evidence: obligations in industry-research partnerships
(2020-03)Which treatment is best for me? This question is at the centre of the clinical consultation. And yet, too often, the question is not answerable with available evidence on drugs and devices. The two Lancet Series papers on ... -
Ethical Issues in Consent for the Re-use of Data in Health Data Platforms
(2020-12)Data platforms represent a new paradigm for carrying out health research. In the platform model, datasets are pooled for remote access and analysis, so novel insights for developing better stratified and / or personalised ... -
Extracting data from diagnostic test accuracy studies for meta-analysis
(2021-01)It is important that DTA reviews summarise all the available evidence. Studies in which the necessary information is not fully reported should not necessarily be excluded from pooled analyses. As reported in this article, ... -
Gamifying Bioethics: A Case Study of Co-Designing Empirical Tools with Adolescents
(2020-07)Research in bioethics largely relies on interviews and surveys, which engage participants with scenarios that are distal in time and place to an actual situation. However, context and embodiment are relevant to moral ... -
How to build a game for empirical bioethics research: The case of ‘Tracing Tomorrow’
(2021-10)It is becoming increasingly clear that the field of empirical bioethics requires methodological innovations that can keep up with the scale and pace of contemporary research in health and medicine. With that in mind, we ... -
Impact of placebo arms on outcomes in antidepressant trials: systematic review and meta-regression analysis
(2018-06)There is debate in the literature as to whether inclusion of a placebo arm may alter characteristics of antidepressant trials. However, previous research has focused on response rates of various antidepressants on average ... -
Informing National Health Service patients about participation in clinical research: A comparison of opt-in and opt-out approaches across the United Kingdom
(2020-11)Objective: Recruitment to clinical research in the National Health Service remains challenging. One barrier is accessing patients to discuss research participation. Two general approaches are used in the United Kingdom ... -
Investigating assumptions of vulnerability: A case study of the exclusion of psychiatric inpatients as participants in genetic research in low‐ and middle‐income contexts
(2020-01)Psychiatric genetic research investigates the genetic basis of psychiatric disorders with the aim of more effectively understanding, treating, or, ultimately, preventing such disorders. Given the challenges of recruiting ... -
Investigating causal mechanisms in randomised controlled trials
(2019-08)Introduction: In some randomised trials, the primary interest is in the mechanisms by which an intervention exerts its effects on health outcomes. That is, clinicians and policy-makers may be interested in how the intervention ... -
The Kilim plot: A tool for visualizing network meta‐analysis results for multiple outcomes
(2020-06)Network meta‐analysis (NMA) can be used to compare multiple competing treatments for the same disease. In practice, usually a range of outcomes is of interest. As the number of outcomes increases, summarizing results from ... -
Living network meta-analysis compared with pairwise meta-analysis in comparative effectiveness research: empirical study
(2018-02-28)Objective:To examine whether the continuous updating of networks of prospectively planned randomised controlled trials (RCTs) (“living” network meta-analysis) provides strong evidence against the null hypothesis in comparative ... -
Managing resources and reducing waste in healthcare settings
(2015-12)The NHS is under pressure to increase its effectiveness and productivity. Nurses are tasked with delivering effective and efficient care, as well as improving patient safety, experiences and results. The reduction of ... -
Measuring the impact of participatory research in psychiatry: How the search for epistemic justifications obscures ethical considerations
(2019-12)Both within politics and practice, the field of psychiatry is undergoing a significant transformation, as increasing emphasis is placed on the importance of involving those with lived experience in research. In response ... -
Mixed effects approach to the analysis of the stepped wedge cluster randomised trial—Investigating the confounding effect of time through simulation
(2018-12)A stepped wedge cluster randomised trial (SWCRT) is a multicentred study which allows an intervention to be rolled out at sites in a random order. Once the intervention is initiated at a site, all participants within that ... -
Network meta-analysis of antidepressants – Authors' reply
(2018-09-22)Comments on issues raised with Cipriani et al, 'Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis' ... -
Patient and public involvement in reducing health and care research waste
(2018-01-08)Background: Eighty five per cent of health research expenditure is potentially wasted due to failure to publish research, unclear reporting of research that is published, and the failure of new research studies to ... -
Pharmaceutical industry, academia and people with experience of mental illness as partners in research: a need for ethical guidance [version 1; peer review: 1 not approved]
(2020-08)Background: Several social and policy developments have led to research partnerships in mental health research, which depart from traditional research models. One form of such partnerships is among research institutions, ... -
Producing and using timely comparative evidence on drugs: lessons from clinical trials for covid-19
(2020-10)Since the early days of the novel coronavirus outbreak, a record number of studies have been launched to test several repurposed and new medicines as potential treatments for covid-19 An analysis by the news organisation ... -
Promoting inclusivity by ensuring that all patients with mental health issues are offered research opportunities in the NHS
(2022-01)Research-active clinical services have lower mortality rates and produce higher quality care outcomes, however, recruiting participants to clinical research in the National Health System (NHS) remains challenging.1 A recent ... -
Qualitative study of barriers to clinical trial retention in adults with recently diagnosed type 1 diabetes
(2018-07)Objectives: Regular physical exercise may preserve β cell function in newly diagnosed adults with type 1 diabetes (T1D). However, clinical trials to test this theory require the recruitment and retention of adults with ...