Conditions: Recent submissions
Now showing items 361-380 of 698
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Trauma, mental health and the COVID-19 crisis: are we really all in it together?
(2021-02)As the world adapts to varying levels of social lockdown – and the lifting of restrictions – due to the COVID-19 pandemic, evidence is mounting that quarantine and other social restrictions negatively affect the mental ... -
Stimulating human prefrontal cortex increases reward learning
(2021-01)Work in computational psychiatry suggests that mood disorders may stem from aberrant reinforcement learning processes. Specifically, it is proposed that depressed individuals believe that negative events are more informative ... -
Psychological intervention, antipsychotic medication or a combined treatment for adolescents with a first episode of psychosis: the MAPS feasibility three-arm RCT
(2021-01)Background: When psychosis emerges in young people there is a risk of poorer outcomes, and access to evidence-based treatments is paramount. The current evidence base is limited. Antipsychotic medications show only a small ... -
Six-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19
(2021-01)Background. Neurological and psychiatric sequelae of COVID-19 have been reported, but there are limited data on incidence rates and relative risks. Methods. Using retrospective cohort studies and time-to-event analysis, ... -
The use of Intensive Interaction within a Positive Behavioural Support framework
(2021-01)Positive Behavioural Support (PBS) provides an overarching framework for supporting quality‐of‐life improvements for people who use challenging behaviour. Rapport, or the lack of it, is well understood as a setting factor ... -
Psychological processes mediating the association between developmental trauma and specific psychotic symptoms in adults: a systematic review and meta-analysis
(2021-01)Experiencing psychological trauma during childhood and/or adolescence is associated with an increased risk of psychosis in adulthood. However, we lack a clear knowledge of how developmental trauma induces vulnerability to ... -
Overlap in genetic risk for cross-disorder vulnerability to mental disorders and genetic risk for altered subcortical brain volumes
(2021-01)Background: There have been considerable recent advances in understanding the genetic architecture of psychiatric disorders as well as the underlying neurocircuitry. However, there is little work on the concordance of genetic ... -
Ketamine treatment for depression: qualitative study exploring patient views
(2021-01)Ketamine is a new and promising treatment for depression but comes with challenges to implement because of its potential for abuse. Aims We sought the views of patients to inform policy and practical decisions about ... -
Excessive sleepiness in patients with psychosis: An initial investigation
(2021-01)Clinical experience indicates that excessive sleepiness and hypersomnia may be a common issue for patients with psychosis. Excessive sleepiness is typically ascribed to the sedating effects of antipsychotic medications but ... -
Cognitive therapy for moral injury in post-traumatic stress disorder
(2021-01)Moral injury is the profound psychological distress which can arise following participating in, or witnessing, events which transgress an individual’s morals and include harming, betraying, or failure to help others, or ... -
Induced pluripotent stem cells in psychiatry: a critical review
(2021-01)A key challenge in psychiatry research is the development of high-fidelity model systems that can be experimentally manipulated to explore and test pathophysiological mechanisms of illness. In this respect, the emerging ... -
Quantification of allosteric communications in matrix metalloprotease-1 on alpha-synuclein aggregates and substratedependent virtual screening
(2021-01)Alpha-synuclein (aSyn) has implications in pathological protein aggregations observed in neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. There are currently no approved prevention and cure ... -
Psychological processes mediating the association between developmental trauma and specific psychotic symptoms in adults: a systematic review and meta-analysis
(2021-02)Experiencing psychological trauma during childhood and/or adolescence is associated with an increased risk of psychosis in adulthood. However, we lack a clear knowledge of how developmental trauma induces vulnerability to ... -
The effect of sertraline on emotional processing: secondary analyses of the PANDA randomised controlled trial
(2021-01)Background. According to the cognitive neuropsychological model, antidepressants reduce symptoms of depression and anxiety by increasing positive relative to negative information processing. Most studies of whether ... -
Paranoia in patients attending child and adolescent mental health services
(2021-01)OBJECTIVE: Paranoia may be particularly prevalent during adolescence, building on the heightened social vulnerabilities at this age. Excessive mistrust may be corrosive for adolescent social relationships, especially in ... -
Incidence of neurodegenerative and cerebrovascular diseases associated with antihypertensive drug classes
(2021-01)Antihypertensive drugs (AHTs) are associated with lowered risks of neurodegenerative diseases and stroke. However, the relative risks associated with different AHT classes are unclear. Using an electronic health record ... -
Vascular disease and multiple sclerosis: a post-mortem study exploring their relationships
(2020-09)Vascular comorbidities have a deleterious impact on multiple sclerosis clinical outcomes but it is unclear whether this is mediated by an excess of extracranial vascular disease (i.e. atherosclerosis) and/or of cerebral ... -
The effect of a youth mental health service model on access to secondary mental healthcare for young people aged 14–25 years
(2018-09)Aims and method The Norfolk Youth Service was created in 2012 in response to calls to redesign mental health services to better meet the needs of young people. The new service model transcends traditional boundaries by ... -
School- and class-level variation in self-harm, suicide ideation and suicide attempts in Danish high schools.
(2018-09)AIM: Strong associations have been found between being exposed to self-harm in family and friends and own self-harm in adolescence. Therefore, self-harm and suicide behaviour might tend to cluster within school and school ... -
A Dissociation of the Acute Effects of Bupropion on Positive Emotional Processing and Reward Processing in Healthy Volunteers
(2018-10)Background: Previous research indicates that antidepressants can restore the balance between negative and positive emotional processing early in treatment, indicating a role of this effect in later mood improvement. However, ...