Conditions: Recent submissions
Now showing items 241-260 of 698
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Abstract thinking as a risk factor for the development of posttraumatic stress disorder symptoms in student paramedics
(2021-10)Abstract cognitive processing is characterized by “why?” and “what if?” questions and associated with processes such as rumination and worry. The tendency to think abstractly in response to stress has not been examined as ... -
Delivering CBT-E In an Online Group Format: A Pilot Study in a Child and Adolescent Eating Disorder Service
(2021-10)Background: The increased prevalence of eating disorders during the COVID-19 pandemic has placed services for children and adolescents under immense pressure. The high number of people at medical risk has led to longer ... -
Identifying effective characteristics of behavioral weight management interventions for people with serious mental illness: A systematic review with a qualitative comparative analysis
(2021-10)People with serious mental illness (SMI) have identified barriers to engaging in behavioral weight management interventions (BWMIs). We assessed whether BWMIs that addressed these barriers were more effective. First, we ... -
Characterising the severity of treatment resistance in unipolar and bipolar depression
(2021-10)Treatment-resistant depression (TRD) is classically defined according to the number of suboptimal antidepressant responses experienced, but multidimensional assessments of TRD are emerging and may confer some advantages. ... -
Weight change, cardio-metabolic risk factors and cardiovascular incidence in people with serious mental illness: protocol of a population-based cohort study in the UK from 1998 to 2020
(2021-11)Introduction: People with serious mental illness (SMI), which includes people with diagnoses of schizophrenia spectrum and bipolar disorders, face significant health inequality. This includes a life expectancy reduced by ... -
The impact of Patient and Public Involvement in the SlowMo study: Reflections on peer innovation
(2021-09)Background: The SlowMo study demonstrated the effects of SlowMo, an eight-session digitally supported reasoning intervention, on paranoia in a large-scale randomized-controlled trial with 362 participants with schizophre ... -
Effect of trazodone on cognitive decline in people with dementia: Cohort study using UK routinely collected data
(2021-09)Evidence in mouse models has found that the antidepressant trazodone may be protective against neurodegeneration. We therefore aimed to compare cognitive decline of people with dementia taking trazodone with those taking ... -
Sleep and circadian rhythm actigraphy measures, mood instability and impulsivity: A systematic review
(2021-09)The normal spectrum trait measures of mood instability and impulsivity are implicated in and comprise core symptoms of several psychiatric disorders. A bidirectional relationship between these traits and sleep disturbance ... -
Suicidal Thoughts in Patients With Cancer and Comorbid Major Depression: Findings From a Depression Screening Program
(2021-09)Major depression is found in around ten percent of patients attending cancer clinics. One of the symptoms of major depression, defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM), is “thoughts of ... -
Comparative efficacy and acceptability of psychotherapies for post-traumatic stress disorder in children and adolescents: a systematic review and network meta-analysis
(2021-10)Background Available evidence on the comparative efficacy and acceptability of psychotherapies for post-traumatic stress disorder (PTSD) in children and adolescents remains uncertain. Objective We aimed to compare and ... -
The costs of bipolar disorder in the United Kingdom
(2021-09)Objectives: To estimate the individual cost and population-level economic burden of Bipolar Disorder (BD), and explore the impact of clinical and sociodemographic factors on costs in the United Kingdom. Methods: Annual ... -
Initial treatment choices to achieve sustained response in major depression: a systematic review and network meta-analysis
(2021-10)Major depression is often a relapsing disorder. It is therefore important to start its treatment with therapies that maximize the chance of not only getting the patients well but also keeping them well. We examined the ... -
Severity of Post-Stroke Cognitive Impairment Moderates the Relationship Between Cognitive Change and Emotional Distress in the Months Following Stroke
(2021-09)Depression and anxiety are common psychological consequences of stroke. Here, we investigated the relationships between cognitive change following stroke, awareness of cognitive impairments, and mood to further understanding ... -
Resting state functional connectivity patterns as biomarkers of treatment response to escitalopram in patients with major depressive disorder
(2021-09)With no available response biomarkers, matching an appropriate antidepressant to an individual can be a lengthy process. Improving understanding of processes underlying treatment responsivity in depression is crucial for ... -
Longitudinal Changes in Parkinson’s Disease Symptoms with and Without Rapid Eye Movement Sleep Behavior Disorder: The Oxford Discovery Cohort Study
(2021-08)Background: Parkinson’s disease (PD) comorbid with rapid eye movement sleep behavior disorder (RBD) may show more severe motor and non motor symptoms, suggesting a distinct PD subtype. Objective: The aim of this study was ... -
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
(2021-08)Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated promising clinical effects in patients with depression. However, the mechanisms through which pramipexole might alleviate depressive symptoms ... -
Critical Developmental Windows of Voltage-Gated Cation Channel Expression in Psychiatric Disorders
(2021-09)The molecular underpinnings of psychiatric disorders remain elusive despite there being a paramount need to establish druggable targets for their treatment. Genome-wide association studies (GWASs) have identified numerous ... -
The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action
(2021-08)The use of SSRIs for the treatment of depression and anxiety in young people is increasing. However, the effects of SSRIs in adolescence, a time when there are substantial changes in neural, cognitive, and social functioning, ... -
Appraisal of patient-level health economic models of severe mental illness: systematic review
(2021-08)Healthcare decision makers require accurate long-term economic models to evaluate the cost-effectiveness of new mental health interventions. Aims To assess the suitability of current patient-level economic models to ... -
Effect of lithium on circadian rhythm in bipolar disorder: A systematic review and meta-analysis
(2021-03)Circadian rhythm disruption is commonly reported in patients with bipolar disorder. Lithium has been suggested to have effects on the circadian clock, the biological basis of the circadian rhythm. The objective of the ...