Conditions: Recent submissions
Now showing items 221-240 of 698
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Dose–effect meta-analysis for psychopharmacological interventions using randomised data
(2022-01)Objective The current practice in meta-analysis of the effects of psychopharmacological interventions ignors the administered dose or restricts the analysis in a dose range. This may introduce unnecessary uncertainty and ... -
Selective publication of antidepressant trials and its influence on apparent efficacy: Updated comparisons and meta-analyses of newer versus older trials
(2022-01)Valid assessment of drug efficacy and safety requires an evidence base free of reporting bias. Using trial reports in Food and Drug Administration (FDA) drug approval packages as a gold standard, we previously found that ... -
Anticipating PTSD in severe COVID survivors: the case for screen-and-treat
(2022-01)Based on research from previous pandemics, studies of critical care survivors, and emerging COVID19 data, we estimate that up to 30% of survivors of severe COVID will develop PTSD. PTSD is frequently undetected across ... -
The Acceptability of a Smartphone App (BlueIce) for University Students Who Self-harm
(2022-01)University students are twice as likely to self-harm than community controls but, unfortunately, help-seeking among this population is particularly low. Given the stigma around self-harm, the face-to-face nature of traditional ... -
Patient attitudes towards remote memory clinic assessment
(2021-12)Background: Due to demand on UK memory clinic services, most patients have limited consultant interaction before diagnosis/discharge. Technology offers an opportunity for remote assessment, from telephone/video-based ... -
Association of Schizophrenia Spectrum Disorders and Violence Perpetration in Adults and Adolescents From 15 Countries A Systematic Review and Meta-analysis
(2021-12)Violence perpetration outcomes in individuals with schizophrenia spectrum disorders contribute to morbidity and mortality at a population level, disrupt care, and lead to stigma. Objective : To conduct a systematic ... -
Treatment-resistant depression: therapeutic options when first-line treatments fail
(2021-12)The Cochrane review by Davies et al aimed to address the lack of clarity on the risks and benefits of switching and augmentation strategies in the pharmacological treatment of treatment-resistant depression in adults who ... -
Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia
(2021-12)The cognitive dysfunction experienced by patients with schizophrenia represents a major unmet clinical need. We believe that enhancing synaptic function and plasticity by targeting kalirin may provide a novel means to ... -
Neurons derived from individual early Alzheimer’s disease patients reflect clinical vulnerability
(2021-11)Modelling sporadic Alzheimer’s disease (sAD) with patient-derived induced pluripotent stem cells (iPSCs) is challenging yet remains an important step in understanding the disease. Here we report a novel approach of sAD ... -
Motivational Interviewing-based interventions for reducing substance misuse and increasing treatment engagement, retention, and completion in the homeless populations of high-income countries: An equity-focused systematic review and narrative synthesis
(2021-11)Rising mortality and disease prevalence in the homeless have been largely attributed to addiction disorders. This review aimed to assess whether Motivational Interviewing (MI) is effective in changing substance misuse ... -
Direct costs of hospital care of self-harm: A national register-based cohort study
(2021-11)Objective To estimate national direct hospital costs associated with treatment of self-harm and to analyse whether costs differ with respect to demographic and clinical characteristics. Methods A cohort design was applied ... -
Exercise versus usual care after non-reconstructive breast cancer surgery (UK PROSPER): multicentre randomised controlled trial and economic evaluation
(2021-11)Objective To evaluate whether a structured exercise programme improved functional and health related quality of life outcomes compared with usual care for women at high risk of upper limb disability after breast cancer ... -
A web-based life-style, exercise and activity intervention for people with progressive multiple sclerosis: Results of a single-arm feasibility study
(2021-11)Background People with progressive Multiple Sclerosis often struggle to access appropriate and inclusive support for regular physical activity. The Lifestyle, Exercise and Activity Package (LEAP-MS) intervention, is a ... -
No antidepressant-like acute effects of bright light on emotional information processing in healthy volunteers
(2021-11)Rationale: Bright light treatment (BLT) is an efficacious antidepressant intervention, but its mechanism of action is not well understood. Antidepressant drugs acutely affect how emotional information is processed, pushing ... -
Over-the-counter analgesics use is associated with pain and psychological distress among adolescents: a mixed effects approach in cross-sectional survey data from Norway
(2021-11)Over-the-counter analgesics (OTCA) such as Paracetamol and Ibuprofen are frequently used by adolescents, and the route of administration and access at home allows unsupervised use. Psychological distress and pain occur ... -
Knowledge and Use of Novel Psychoactive Substances in Italy: a Survey-Based Study in the General Population
(2021-11)In this study, we aimed to identify the current trend of novel psychoactive substance (NPS) consumption in Italy and the level of knowledge about NPS in the general population and to explore the presence of risk factors ... -
Computer-vision aided functional movement measurement in people with and without axial spondyloarthritis – validation and feasibility study protocol
(2021-11)Back pain is a common form of disability worldwide,and one condition that causes chronic back pain is axial spondyloarthritis (axSpA) which primarily affects spinal joints resulting in pain and joint stiffness. There ... -
Dissociation in patients with non-affective psychosis: Prevalence, symptom associations, and maintenance factors
(2021-11)Dissociation is problematic in its own right for patients with psychosis but may also contribute to the occurrence of psychotic experiences. We therefore set out to estimate in a large cohort of patients with psychosis the ... -
Women in psychiatry and women's mental health
(2021-11)Women are increasingly well represented in psychiatry as a profession, but data show us that it is not a level playing eld. Written by the Chairs of the Women and Mental Health Special Interest Group (WMHSIG) of the Royal ... -
Substance use disorder treatment success: assessing patient-reported use improvement and provider-evaluated treatment completion
(2021-11)Provider-evaluated substance use treatment completion and client-reported substance use improvement are standards in determining treatment success. The relationship between these two outcomes is anecdotally understood in ...