Browsing Conditions by Author "External author(s) only"
Now showing items 1-20 of 88
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Antimicrobial Peptides SLPI and Beta Defensin-1 in Sputum are Negatively Correlated with FEV1
External author(s) only (2021-05)Background: Chronic obstructive pulmonary disease (COPD) and asthma have heterogeneous inflammation with inhaled corticosteroids (ICS) as a mainstay of treatment. There is increased prevalence of non-typeable Haemophilus ... -
Assessing Fluid Resuscitation in Adults with Sepsis Who Are Not Mechanically Ventilated: a Systematic Review of Diagnostic Test Accuracy Studies
External author(s) only (2019-05)BACKGROUND: Fluid resuscitation is a widely used intervention that is mandated in the management of sepsis. While its use can be life-saving, its overuse is associated with harm. Despite this, the best means of assessing ... -
Association of midlife stroke risk with structural brain integrity and memory performance at older ages: a longitudinal cohort study
External author(s) only (2020-03)Cardiovascular health in midlife is an established risk factor for cognitive function later in life. Knowing mechanisms of this associationmay allow preventative steps to be taken to preserve brain health and cognitive ... -
Barriers and facilitators of loaded self-managed exercises and physical activity in people with patellofemoral pain: understanding the feasibility of delivering a multicentred randomised controlled trial, a UK qualitative study
External author(s) only (2019-05)Objectives: There is an emergent body of evidence supporting exercise therapy and physical activity in the management of musculoskeletal pain. The purpose of this study was to explore potential barriers and facilitators ... -
Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol
External author(s) only (2018-11)Introduction: Neurogenic claudication due to spinal stenosis is common in older adults. The effectiveness of conservative interventions is not known. The aim of the study is to estimate the clinical and cost-effectiveness ... -
Blood pressure changes following antihypertensive medication reduction, by drug class and dose chosen for withdrawal: Exploratory analysis of data from the OPTiMISE trial
External author(s) only (2021-02)Aims: Deprescribing of antihypertensive drugs is recommended for some older patients with polypharmacy, but there is little evidence to inform which drug (or dose) should be withdrawn. This study used data from the ... -
Brain tumour segmentation using a triplanar ensemble of U-Nets on MR images
External author(s) only (2021-05)Gliomas appear with wide variation in their characteristics both in terms of their appearance and location on brain MR images, which makes robust tumour segmentation highly challenging, and leads to high inter-rater ... -
Changing paramedic students' perception of people who self-harm
External author(s) only (2020-10)This study aimed to identify whether paramedic students' perceptions of patients who self-harm changed following an educational intervention. Background: Self-harm is a major public health concern with an increasing ... -
Characterising the severity of treatment resistance in unipolar and bipolar depression
External author(s) only (2021-10)Treatment-resistant depression (TRD) is classically defined according to the number of suboptimal antidepressant responses experienced, but multidimensional assessments of TRD are emerging and may confer some advantages. ... -
Clinical prediction tools to identify patients at highest risk of myeloma in primary care: a retrospective open cohort study
External author(s) only (2021-04)Background Patients with myeloma experience substantial delays in their diagnosis, which can adversely affect their prognosis. Aim To generate a clinical prediction rule to identify primary care patients who are at highest ... -
Cognitive Performance, Quality and Quantity of Movement Reflect Psychological Symptoms in Adolescents
External author(s) only (2020-05)The presentation of unhealthy psychological symptoms are rising sharply in adolescents. Detrimental lifestyle behaviours are proposed as both possible causes and consequences. This study set out to compare selected ... -
Conceptual Framework for an Episode of Rehabilitative Care After Surgical Repair of Hip Fracture
External author(s) only (2019-03)Researchers face a challenge when evaluating the effectiveness of rehabilitation after a surgical procedure for hip fracture. Reported outcomes of rehabilitation will vary depending on the end point of the episode of care. ... -
Connections Between Insomnia and Cognitive Aging.
External author(s) only (2019-06)Insomnia is a common sleep disorder among older adults, and a risk factor for poor physical and mental health. However, the relationship between insomnia and cognitive health is not well understood. Here, we review ... -
Defining the relationship between arm and leg blood pressure readings: a systematic review and meta-analysis
External author(s) only (2019-04)Objectives: To define the relationship between arm and leg blood pressure (BP) to inform the interpretation of leg BP readings in routine clinical practice where arm readings are not available. Methods: Systematic review ... -
Deprescribing antihypertensives in patients with multimorbidity
External author(s) only (2020-10)Deprescribing preventative medications such as antihypertensives may reduce adverse events in some older adults, leading to improved quality of life. The Optimising Treatment for Mild Systolic Hypertension in the ... -
Developing Clinical Guidelines for Dietitians Treating Young People with Anorexia Nervosa - Family Focused Approach Working Alongside Family Therapists
External author(s) only (2019-05)Introduction: Family therapy for the treatment of Anorexia Nervosa (AN) in an outpatient setting is the evidenced based model of care. Nutritional intervention is an essential component in the treatment of AN particularly ... -
Development and implementation of the physiotherapy-led exercise interventions for the treatment of rotator cuff disorders for the ‘Getting it Right: Addressing Shoulder Pain’ (GRASP) trial
External author(s) only (2019-07)Objectives: The Getting it Right: Addressing Shoulder Pain (GRASP) trial is a large-scale, multicentre, 2 × 2 factorial randomised controlled trial investigating clinical and cost-effectiveness of a progressive exercise ... -
Development and Validation of a Novel Dementia Risk Score in the UK Biobank Cohort
External author(s) only (2021-03)INTRODUCTION: Current prognostic models of dementia have had limited success in consistently identifying at-risk individuals. We aimed to develop and validate a novel dementia risk score (DRS) using the UK Biobank cohort. ... -
Development of a core outcome set for lower limb orthopaedic surgical interventions in ambulant children and young people with cerebral palsy: a study protocol
External author(s) only (2020-03)Introduction Musculoskeletal deformities and gait deviations are common features in ambulatory cerebral palsy (CP). Deformity correction through lower limb orthopaedic surgery is the standard form of care aimed at improving ... -
Diagnosis Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Syndrome
External author(s) only (2019-12)IMPORTANCE: Atypical parkinsonian syndromes (APS), including progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and multiple system atrophy (MSA), may be difficult to distinguish in early stages and are ...